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Effect of isolation on barbiturate anaesthesia in the rat (1976)

Einon, Dorothy ; Stewart, Jane ; Atkinson, Suzanne ; [et al.]

Springer

Psychopharmacology 50 (1976), S. 85-88

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ISSN: 1432-2072

Keywords: Barbiturate-anaesthesia ; Social-isolation ; Diurnal-rhythm ; Sex-differences ; Arousal ; Rats

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract The duration of barbiturate-induced sleeping in rats was found to be reduced by isolation housing. It was also lower in males than females, and lower in the dark phase of the diurnal cycle. These variables were shown to be additive in their effects. Sex differences in barbiturate action were found to be reduced by gonadectomy in males; and the effects of isolation were found to depend upon housing conditions at the time of testing rather than upon early rearing environment. The implication for theories of arousal is discussed.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00634160

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