ISSN:
1432-2013
Keywords:
Renin
;
Extrarenal Renin
;
Noradrenaline
;
Vasopressin Phenoxybenzamine
;
Propranolol
;
Arteriolar Tone
;
Antiangiotensin II
;
Vascular Receptors
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Antiangiotensin II plasma induced transitory hypotension in rats when 0.2 ml was injected intravenously in normal males (either awake or anaesthetized), into binephrectomized females or into some males which had been nephrectomized 18–22 or 42–53 hours previously. Antiangiotensin II did not affect the blood pressure of male rats when given between 24 and 26 hours after nephrectomy. Antiangiotensin resulted in a 10–200 fold increase in the dose of angiotensin required to produce a measurable change in blood pressure, and also significantly reduced reactivity to l-noradrenaline. A remaining plasma renin activity was constantly found in binephrectomized females and in most of binephrectomized males. Plasma renin activity was significantly higher in the former than in the latter. It is concluded that angiotensin plays a role in the maintanance of blood pressure, in normal rats, in binephrectomized females and in some binephrectomized males.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00587213
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