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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 56 (1978), S. 917-920 
    ISSN: 1432-1440
    Keywords: Pancreas extracts ; Pancreas secretions ; Aryl-esterases ; Fluoresceinedilaurate ; Test of pancreatic function ; Pankreashomogenat ; Pankreassekret ; Aryl-Esterasen ; Fluoresceindilaurat ; Pankreasfunktionstest
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Auftrennung von Pankreashomogenat und Pankreassekret sowie von Serum Pankreatitis-Kranker führt zu 3 Esterasen verschiedenen Molgewichts, von denen keine mit Lipase identisch ist. Als Substrate für diese als Aryl-Esterasen zu klassifizierenden Enzyme dienen Fluoresceinester, die in einem oralen Pankreasfunktionstest verwendet werden können. Dabei erreichen gesunde Personen eine relative Fluoresceinausscheidung im 10-Stunden-Sammelurin von 66,3±30,4%, Patienten mit Pankreasinsuffizienz von 12,7±9,8%.
    Notes: Summary Column chromatography of extracts and secretions of the pancreas as well as of sera from patients suffering from inflammations of this organ yields three esterases different from each other in molecular size. These enzymes could be shown to be not identical with lipase. They may be classified as aryl-esterases considering their activities in hydrolyzing synthetic substrates such as esters of fluoresceine with fatty acids. Fluoresceinedilaurate, therefore, proved to be very advantageous in an orally performed test of exocrine pancreatic function. Healthy persons show in this procedure relative excretion of fluoresceine during ten hours of 66.3±30.4%, patients suffering from pancreatic diseases only 12.7±9.8% of the dye.
    Type of Medium: Electronic Resource
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