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  • 1
    Electronic Resource
    Electronic Resource
    Stimulating effect of ascorbic acid on ascites tumor cell multiplication in vitro (1983)
    Springer
    Journal of cancer research and clinical oncology 106 (1983), S. 69-70 
    Details
    ISSN: 1432-1335
    Keywords: Ascorbic acid ; Ascites tumor cells ; Cell multiplication
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a preceding report evidence has been presented that ascorbic acid (AA) accelerated solid tumor growth obtained by inoculating tumor ascites cells into the subcutaneous dorsal region of inbred Balb/cf/Had/Se substrain mice. The present work investigates whether this effect is the results of a direct action of AA on neoplastic cell multiplication or of an indirect action on the tumor cells mediated by changes induced by AA in the organism bearing the tumor. The results obtained demonstrate that AA at low doses (μg 10–30/ml) stimulates ascites tumor cell multiplication in vitro, while at high doses (μg 60–120/ml) the opposite occurs. These results suggest that the major growth of solid tumors observed in mice treated with AA may be attribute to the capacity of this substance to favor the multiplication of ATP cells which were used to induce the tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00399900
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of ascorbic and dehydroascorbic acid on the multiplication of tumor ascites cells in vitro (1984)
    Springer
    Journal of cancer research and clinical oncology 108 (1984), S. 230-232 
    Details
    ISSN: 1432-1335
    Keywords: Ascorbic acid ; Dehydroascorbic acid ; Ascites cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of AA and DHA on ATP C+ cell multiplication in vitro were studied by measuring incorporation of 3H thymidine into DNA. The results obtained demonstrate that both AA and DHA have the same effects: they favor cell multiplication at low doses and inhibit it at high doses. Experiments carried out with serial doses of both these substances revealed that AA is more efficient in determining both stimulating and inhibiting effects. The lesser efficiency of DHA may be attributed to its limited stability in culture medium. Studies on the effect of high doses of AA and DHA added to the culture medium in single or fractionated doses revealed that fractionated administration is more efficient in inhibiting cell multiplication than single administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00402472
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Production and characterization of monoclonal antibodies to the mammalian sperm cytoskeleton (1990)
    New York, NY [u.a.] : Wiley-Blackwell
    Molecular Reproduction and Development 25 (1990), S. 384-392 
    Details
    ISSN: 1040-452X
    Keywords: Immunofluorescence ; Immunoblotting ; Spermatozoa ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: The cytoskeleton exerts a direct effect on the function of sperm by influencing the distribution of subcellular organelles and plasma membrane molecules. We have prepared six monoclonal antibodies to Triton X-100-insoluble components of the bull sperm cytoskeleton. One of the antibodies reacts with a detachable portion of the bull sperm acrosome. The remainder include an antibody that recognizes the principal and end piece of the tail and another that is specific to the middle piece. Two of the antibodies yield dissimilar staining patterns of the neck region and the tail, and the final monoclonal antibody stains the subacrosomal region and a detachable acrosomal domain of bull sperm. The cross reactivities of the antibodies with hamster sperm and PtK2 cells are described, as is the recognition of bull sperm polypeptides on western blots. The results suggest that these antibodies will provide interesting insights concerning the role of the cytoskeleton in sperm development and function.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrd.1080250412
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    Paper (German National Licenses)
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