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Digitale Medien

Untersuchungen der Zentralnervösen sympathicusdÄmpfenden Wirkungen von α-Methyl-dopa (1971)

Tauberger, G. ; Kuhn, P.

Springer

Naunyn-Schmiedeberg's archives of pharmacology 268 (1971), S. 33-43

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ISSN: 1432-1912

Schlagwort(e): Arterial Blood Pressure ; Action Potentials ; Central Sympathetic Activity ; Central Respiratory Activity ; α-Methyl-dopa ; Arterieller Blutdruck ; Aktionspotentiale Zentrale SympathicusaktivitÄt ; Atemzentrum ; α-Methyl-dopa

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary The centralnervous sympathetic inhibitory and hypotensive effects ofα-methyl-dopa were studied in anaesthetized rats and cats. Preganglionic action potentials of the cervical sympathetic nerve were recorded simultaneously with the arterial blood pressure and evaluated quantitatively. Student'st-test was applied for statistical analysis. The experiments show thatα-methyl-dopa produces no significant hypotensive or sympathetic inhibitory effects at a dosage of 400 mg/kg i. v. during a 2 hr period after administration. Only after pretreatment for 4 consecutive days with a total dosage of 400–2000 mg/kg i.p. was there an inhibition of the spontaneous sympathetic activity as well as of that induced by nikethamide or asphyxia. Therefore the blockade affected not only the reflex but also the primarily central nervous patterns of discharges in the sympathetic nerve. Although a depression of sympathetic activity was already observed with doses which failed to produce a significant fall in blood pressure, our results suggest that a central nervous mechanism of action participates in the hypotensive effect ofα-methyl-dopa.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00997171

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Digitale Medien

Mössbauer-Spektren von Eisenphthalocyanin-Komplexen (1969)

Taube, R. ; Drevs, H. ; Fluck, E. ; [weitere]

Weinheim : Wiley-Blackwell

Zeitschrift für anorganische Chemie 364 (1969), S. 297-315

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ISSN: 0044-2313

Schlagwort(e): Chemistry ; Inorganic Chemistry

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Beschreibung / Inhaltsverzeichnis: The Mössbauer spectra of iron(II)-phthalocyanine, FePc, its anionic complexes of the type [FePc]n- (n = 1, 2, 3, 4) and the cation [FePc]+ were recorded at various temperatures. The isomeric shifts and quadrupole splittings and their dependence on temperature are discussed on the basis of a MO treatment of the complexes.

Notizen: Die Mössbauer-Spektren des Eisen(II)-phthalocyanins, FePc, der anionischen Komplexe des Typs [FePc]n- (n = 1, 2, 3, 4) und des Kations [FePc]+ wurden bei verschiedenen Temperaturen aufgenommen. Die Isomerieverschiebungen und Quadrupolaufspaltungen und ihre Temperaturabhängigkeit sind auf der Grundlage einer MO-Behandlung der Komplexe interpretiert.

Zusätzliches Material: 7 Ill.