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TUNEL-positive hepatocytes in alcoholic liver disease (1997)

Zhao, Ming ; Laissue, Jean A. ; Zimmermann, A.

Springer

Virchows Archiv 431 (1997), S. 337-344

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ISSN: 1432-2307

Keywords: Key words Apoptosis ; TUNEL ; Hepatocytes ; Alcoholic liver disease

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Alcohol-induced damage to the liver results in a wide array of typical alterations. Whereas the mechanisms involved in the pathogenesis of fatty change, hepatocyte ballooning, Mallory body formation and fibrosis have been studied in detail, little is known about hepatocyte apoptosis in alcoholic liver disease (ALD). In this retrospective study we analysed parenchymal cell death in ALD systematically by the use of in situ DNA nick-end labelling (ISEL/TUNEL). We show that increased hepatocyte TdT labelling occurs in ALD. Labelling is observed more frequently in parenchymal areas exhibiting advanced damage (ballooning degeneration with or without Mallory bodies, cholestasis and perisinusoidal fibrosis). In addition, hepatocyte TdT labelling is higher where there is septal fibrosis and nodular remodelling. Conversely, it is not elevated in ballooning hepatocytes themselves, but rather in the apparently normal hepatocytes in their vicinity.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s004280050108

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Computational studies of peripheral ring twisting in meso-N-methyl pyridyl-substituted porphyrins (1993)

Monaco, Regina R. ; Zhao, Ming

New York, NY : Wiley-Blackwell

International Journal of Quantum Chemistry 46 (1993), S. 701-709

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ISSN: 0020-7608

Keywords: Computational Chemistry and Molecular Modeling ; Atomic, Molecular and Optical Physics

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: Semiempirical molecular orbital calculations for the porphyrins tetrakis(4-N-methyl pyridyl)porphine (H2TMpyP-4) and tetrakis(2-N-methyl pyridyl)porphine using the MNDO and AM-1 Hamiltonians suggest that twisting one or more of the pyridinium rings results, at considerable energy expense, in highly nonplanar macrocycle configurations as the exocyclic ring(s) approach coplanarity. The results imply that the mechanism of intercalation of H2TMpyP-4 into DNA cannot require twisting the exocyclic rings anywhere close to coplanarity with the central porphine core, but involves, instead, the inherent flexibility of DNA itself. © 1993 John Wiley & Sons, Inc.

Additional Material: 10 Tab.