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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 366 (1975), S. 177-186 
    ISSN: 1432-2307
    Keywords: Urinary Tract ; Bladder ; Urothelium ; Inverted Papilloma ; Transitional Cell Carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Five new cases of inverted urinary papilloma are described and 13 previously reported cases are reviewed. All 18 examples were seen in adult males, with ages ranging from 26 to 79 years (average 57 years). Ten patients presented with symptoms of bladder outlet obstruction and 8 with haematuria. With one probable exception all of the tumours were solitary. Sixteen were found in the region of the bladder neck and prostatic urethra, and only 2 occurred in other sites. The papillomas were pedunculated or sessile and ranged in size from a few mms to 3 cms in greatest diameter. Most had smooth surfaces in contrast to the usual exophytic papillary urothelial neoplasms. Microscopically they showed a striking resemblance to the inverted papillomas of the nasal cavity and paranasal sinuses. In those examples where the stalk or base of the papilloma was included in the sections, there was no evidence of invasion of the underlying smooth muscle. Fourteen of the patients have been followed for periods ranging from 7 months to 11 years (average 2.5 years) and no recurrences have been documented. Simple local resection, by the transurethral route where possible, appears to be adequate treatment for these distinctive papillomas.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 224 (1979), S. 111-116 
    ISSN: 1434-4726
    Keywords: Auditory nerve fiber ; Acoustic trauma ; Hair cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Four chinchillas were exposed for 5 days to an octave band of noise centered at 4 kHz and having an SPL of 86 dB. After a recovery period of approximately 6 months, behavioral audiograms were obtained and auditory nerve fiber activity was recorded. The animals were killed and the cochleas embedded in plastic to obtain a surface preparation and 1 μ radial sections of the organ of Corti. Behavioral threshold shifts ranged from 5 to 20 dB at frequencies between 4 and 11 kHz. Auditory nerve fiber thresholds were elevated up to 70 dB for units with characteristic frequencies between 4 and 14 kHz. Units with higher and lower characteristic frequencies had normal thresholds. Cochleagrams showed narrow lesions of inner and/or outer hair cells over approximately a 1 mm distance. A comparison of the three realms of data revealed the following: (1) The greatest threshold shifts from the noise exposure were seen in the single nerve fiber thresholds while the smallest shifts were seen in the behavioral thresholds, (2) the greatest behavioral and neural threshold shifts and greatest cochlear damage occurred 1 octave above the center frequency of the noise exposure, and (3) based on the frequency-place map of the chinchilla cochlea, the range of fibers with elevated thresholds exceeded the extent of the OHC lesion. A number of anatomical changes were seen that effectively increased the extent of the damage found in the chochleagram. These changes included: distortions in the surface topography of the organ of Corti affecting the orientation of IHC; missing pillar cells in the presence of normal OHC and/or IHC and protrusion of the IHC cuticular plate into the subtectorial space.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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