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  • Capsaicin  (3)
  • 25.70.Lm  (1)
  • Autonomic neurones  (1)
  • 1
    Digitale Medien
    Digitale Medien
    The effect of capsaicin on afferent nerves and temperature regulation of mammals and birds
    Amsterdam : Elsevier
    Journal of Thermal Biology 11 (1986), S. 95-100 
    Details
    ISSN: 0306-4565
    Schlagwort(e): Capsaicin ; desensitization ; hypothalamic neurones ; nociception ; sensory neurones ; substance P ; temperature reception ; temperature regulation
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0306-4565(86)90026-4
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  • 2
    Digitale Medien
    Digitale Medien
    Efferent functions of C-fiber nociceptors (1998)
    Springer
    Zeitschrift für Rheumatologie 57 (1998), S. S8 
    Details
    ISSN: 0340-1855
    Schlagwort(e): Key words ; Antidromic vasodilatation ; axon reflex ; flare reaction ; plasma extravasation ; substance P ; calcitonin gene-related peptide ; galanin ; capsaicin ; fibromyalgia ; Schlüsselwörter ; Antidrome Vasodilatation ; Axonreflex ; Flarereaktion ; Plasmaextravasation ; Substanz P ; Calcitonin Gene-Related Peptide ; Galanin ; Capsaicin ; Fibromyalgie
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung C-Faser Nozizeptoren haben neben ihrer afferenten auch lokale efferente Funktionen, wie Vasodilatation, Plasmaextravasation und die Modulation neuronaler Aktivität, die durch Freisetzung der Neuropeptide Substanz P, Neurokinin A und Calcitonin Gene-Related Peptide (CGRP) an der peripheren Endigung ausgelöst werden. In der Haut der Säugetiere (einschließlich Mensch) ist CGRP der wichtigste Mediator der Flarereaktion. Die Vasodilatation wird beim Schwein durch Aktivierung von spezifischen Hitzenozizeptoren induziert. Bei der Taube wird die antidrome Vasodilatation durch intrinsisch freigesetztes Galanin gehemmt. Plasmaextravasation kann beim Schwein in Hautblasen und mit der Mikrodialyse durch Histaminsuperfusion, nicht aber durch elektrische Stimulation und Capsaicin, ausgelöst werden. Die neurogene Komponente der Histaminantwort (64%) wird durch NK2-Rezeptoren vermittelt und kann durch CGRP moduliert werden. Die genannten Neuropeptide können zur Sensibilisierung und unter bestimmten Bedingungen zur Stimulation von Nozizeptoren führen. Die erhöhte Sensitivität der Flarereaktion bei Fibromyalgiepatienten deutet auf eine veränderte Funktion der C-Faser Nozizeptoren hin.
    Notizen: Summary C-fiber nociceptors not only serve afferent but also local efferent functions. The local efferent functions, such as vasodilatation, axon reflex flare reaction, plasma extravasation, and modulation of neuronal activity, are mediated via a local release of substance P, neurokinin A, and calcitonin gene-related peptide (CGRP) from the peripheral ending. CGRP is the main mediator of the capsaicin-induced flare reaction in the mammalian skin (including humans). In the pig skin the vasodilatation is due to activation of specific heat nociceptors. In the pigeon, antidromic vasodilatation is markedly inhibited by intrinsic galanin. Plasma extravasation in the pig skin blister base or using microdialysis can be evoked by histamine, but not by electrical stimulation or capsaicin. The neurogenic component of the histamine response (64%) appears to be mediated via NK2 receptors and can be modulated by CGRP. There is some evidence that the neuropeptides can also sensitize or stimulate nociceptors. Since in the fibromyalgia syndrome an increased sensitivity of the flare reaction has been observed, the hyperalgesia might be partly due to altered functions of C-fiber nociceptors.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s003930050226
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  • 3
    Digitale Medien
    Digitale Medien
    Changes in fibre populations of the rat hairy skin following selective chemodenervation by capsaicin (1999)
    Springer
    Cell & tissue research 296 (1999), S. 471-477 
    Details
    ISSN: 1432-0878
    Schlagwort(e): Key words Skin ; Sensory innervation ; Capsaicin ; Protein gene product 9.5 ; Neurogenic inflammation ; Sensory neuropeptides ; Rat (Wistar)
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract  Perineural application of capsaicin results in a selective and permanent reduction in the sensitivity to noxious chemical and heat stimuli and elimination of the neurogenic inflammatory response. The present quantitative immunohistochemical study has been undertaken to reveal the populations of cutaneous afferent nerves that are affected by perineural capsaicin treatment. Areas of intact and chemodenervated skin were determined with the aid of the vascular labelling technique. In sections taken from intact skin areas, staining with antibodies against protein gene product 9.5 revealed a rich epidermal innervation. Fibres immunoreactive for growth-associated protein 43 were also abundant; nerve fibres immunoreactive for substance P and calcitonin gene-related peptide were less numerous. Somatostatin- and RT97-immunoreactive fibres were seen only in the subepidermal layer. In sections taken from skin areas supplied by the sciatic nerve treated with capsaicin 3 days previously, the number of epidermal nerve fibres immunoreactive to protein gene product 9.5, growth-associated protein 43, substance P and calcitonin gene-related peptide was reduced by 90%, 95%, 97% and 66%, respectively. These changes persisted for at least 42 days. The findings reveal that the majority of epidermal axons are capsaicin-sensitive and comprise a chemically heterogeneous population. Reductions in cutaneous fibre populations following perineural capsaicin treatment may result from both the degeneration of sensory axons and the depletion of neuron-specific macromolecules. In addition, most cutaneous nociceptive axons may not use the major sensory neuropeptides substance P and calcitonin gene-related peptide as afferent neurotransmitters.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004410051307
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  • 4
    Digitale Medien
    Digitale Medien
    Neuronal subpopulations in autonomic ganglia associated with the chicken ureter: an immunohistochemical study (1998)
    Springer
    Cell & tissue research 292 (1998), S. 477-485 
    Details
    ISSN: 1432-0878
    Schlagwort(e): Key words Neurochemical coding ; Autonomic neurones ; Somatostatin ; Neuropeptide Y ; Nitric oxide synthase ; Vasoactive intestinal polypeptide ; Substance P
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract The neurochemical coding of neurones located in ganglia of the nerve trunk accompanying the chicken ureter was analysed and quantified using NADPH-diaphorase reactivity and immunohistochemistry against tyrosine hydroxylase (TH), nitric oxide synthase (NOS), calbindin (CAL), vasoactive intestinal polypeptide (VIP), neuropeptide Y (NPY), somatostatin (SOM), substance P (SP) and calcitonin gene-related peptide (CGRP) in untreated or colchicine-treated preparation. Almost all neurones were either positive for TH (38%) or for SOM (60%). Only 4% of the neurones were both TH- and SOM-positive and 3% of the neurones exhibited neither TH nor SOM immunoreactivity. The relative numbers of NPY-, NOS-, CAL- and VIP-positive neurones were 57%, 28%, 14% and 7%, respectively. No SP- or CGRP-positive neurones were observed. All NADPH-diaphorase-positive neurones expressed NOS immunoreactivity. Only in some TH-positive neurones was NPY and/or NOS found. Four major subpopulations were found in the ureteric ganglia. The SOM-positive neurones were subdivided into SOM/NPY/NOS- (28% of all neurones), SOM/NPY- (18%) and SOM/CAL/NPY-positive neurones (14%). A subpopulation of these peptid- ergic neurones also contained VIP. About 35% of the neurones contained TH only. Neurones of all subpopulations (72% of the neurones), except most of the CAL-positive neurones, were encircled by dense plexus of varicose SP/CGRP-positive, presumably sensory nerve fibres. Dense plexus of VIP-positive fibres were observed around 89% of the neurones. The chemical coding of the neuronal subpopulations identified in the ganglia accompanying the chicken ureter resembled that observed in the ganglia of Remak’s nerve but was remarkably different from that of the autonomic neurones described in mammalian species.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004410051076
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  • 5
    Digitale Medien
    Digitale Medien
    Inclusive fragment production in84Kr +197Au atE/A=35 MeV (1993)
    Springer
    The European physical journal 346 (1993), S. 227-236 
    Details
    ISSN: 1434-601X
    Schlagwort(e): 25.70.Lm ; 25.70.Mn ; 25.70.Pq
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract Inclusive cross sections of intermediate mass fragments from the reaction84Kr+197Au atE/A=35 MeV were measured over the range 8°≦Θ lab≦70° with a low detection threshold. A moving-source parameterization was used to fit the double-differential cross sections. The integrated cross section for fragment production exceeds the total reaction cross section thus indicating a large probability for multi-fragment processes. The deduced large temperature parameters can be explained by assuming emission from a rotating source. From the comparison to reactions with12C and40Ar projectiles at E/A=30 MeV a systematics of inclusive fragment production as a function of the projectile mass is obtained.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01306083
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