ISSN:
1432-1076
Keywords:
Key words
;
Prostaglandin E1, E2, F2α and I2 (prostacyclin)
;
Cerebral artery
;
Mesenteric artery
;
Baboons/primate animals
;
Premature newborns
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Responses to prostaglandins (PGs) E1, E2, F2α and I2 at a wide range of concentrations were compared in the cerebral and mesenteric arteries isolated from premature newborn baboons. PGE1 at low concentrations relaxed the cerebral artery but not the mesenteric artery. PGI2 produced a relaxation of similar magnitude in both arteries. PGF2α in high concentrations produced a much greater contraction in the mesenteric artery than in the cerebral artery. Thus, during the perinatal stage, the baboon cerebral artery has distinctive PG-reactivity compared to the extracerebral artery. Clinical use of PGE1 or indomethacin may result in circulatory derangement or redistribution of blood flow in the cerebral and mesenteric circulations, and may produce side effects of these drugs.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00647287
Permalink
