ISSN:
1612-1112
Schlagwort(e):
Ion-exchange chromatography
;
Ion-pair reversed-phase chromatography
;
Pharmaceutical analysis
;
Baclofen
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Chemie und Pharmazie
Notizen:
Summary Chromatography plays a major role in pharmaceutical analysis since classic methods such as titrimetry or direct spectroscopic analyses do not provide sufficient selectivity and/or detectability. Of various chromatographic methods, HPLC offers good resolution and great versatility in handling compounds that are thermally unstable, polar, and non-volatile at low temperatures. Discussed in this paper is an example of a pharmaceutical compound viz. baclofen [4-amino-3-(p-chlorophenyl)butyric acid], a compound with low UV absorptivitiy, where HPLC provides the desired selectivity and detectability to allow precise determinations in the presence of pharmaceutical excipients. Discussed here also are investigations on mechanism of separations by ion-exchange and ion-pair reversed-phase chromatography.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF02268376
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