ISSN:
1432-0533
Keywords:
Bacterial endotoxin
;
Lipopolysaccharide
;
Lipid A
;
Culture astrocyte
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary This report concerns the effect of bacterial endotoxin [lipopolysaccharide(LPS) and lipid A] on cultured human fetal astrocytes. Exposure to 1 μg/ml LPS or lipd A caused a striking stimulation of the rate of proliferation of the cells. The effect was most pronounced with exponentially growing cultures. Stimulation was associated with enhance DNA synthesis as ascertained by [3H]thymidine incorporation. These findings at the cellular level may be of relevance in the elucidation of the effects of bacterial endotoxins on the developing human brain.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00296549
Permalink