ISSN:
1432-1041
Keywords:
Bartter's syndrome
;
Hypokalaemia
;
Captopril
;
ACE-inhibitor
;
lymphocyte sodium and potassium
;
adverse effect
;
plasma renin
;
aldosterone
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The effect of captopril has been investigated in four patients with Bartter's syndrome treated for 12 weeks. Baseline biochemistry showed normal serum aldosterone (mean 347 pmol·l−1) and a mean serum renin of 217 mU·l−1, and a considerable increase in serum renin during captopril treatment. Serum aldosterone decreased gradually during the study period to about half its initial value. The patients presented with a mean serum potassium of 2.5 mmol·l−1, which rose to 3.4 mmol·l−1 on captopril. Lymphocytes showed a substantial captopril-induced increase in intracellular sodium (from 15 to 22.5 mmol·l−1 on average), but no change in the potassium content. Captopril was well-tolerated. It may be an alternative to potassium-sparing diuretics for maintaining normal serum potassium levels in patients with Bartter's syndrome.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00314956
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