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  • Beaufort Sea Mackenzie Delta Thermokarst lake Embayment Arctic Cesium radiocarbon Geochemistry Permafrost Acoustic stratigraphy  (1)
  • immunotherapy  (1)
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  • 1
    Digitale Medien
    Digitale Medien
    Characterisation of marine and lacustrine sediments in a drowned thermokarst embayment, Richards Island, Beaufort Sea, Canada (2000)
    Springer
    International journal of earth sciences 89 (2000), S. 503-521 
    Details
    ISSN: 1437-3262
    Schlagwort(e): Beaufort Sea Mackenzie Delta Thermokarst lake Embayment Arctic Cesium radiocarbon Geochemistry Permafrost Acoustic stratigraphy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Geologie und Paläontologie
    Notizen: Abstract. A multidisciplinary study was made of lakes and lagoons in a thermokarst embayment on Richards Island, Canadian Beaufort Sea, in order to investigate the response of the Mackenzie Delta shoreline to changing hydrological influences. Seismo-acoustic profiles made from an amphibious vehicle, combined with sediment core data, show that the deepest lakes contain up to 10 m of transparent or stratified silty mud overlying the Kittigazuit sand basement. Palynological and microfossil data from 21 surface samples allow delineation of freshwater, saltmarsh, tidal flat and subtidal assemblages. These modern reference data allow distinction of freshwater and marine facies in the cores and subsequent interpretation of geochemical content (carbon, ammonia, sulphate). Radiocarbon dates and 137 Cs show that sedimentation rates have increased by an order of magnitude since drowning of the embayment during the past millennium, and that most of this sediment is from the Mackenzie River plume.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s005310000126
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    New Non-cytotoxic Approaches to Ovarian Cancer (1999)
    Springer
    Annals of oncology 10 (1999), S. 65-68 
    Details
    ISSN: 1569-8041
    Schlagwort(e): drug resistance ; genetic therapy ; immunotherapy ; metalloproteinase inhibitors ; radioconjugates ; signal transduction
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Two recent examples of conventional cytotoxic drugs, taxoids and topo I inhibitors, are set to make a real impact in the treatment of ovarian cancer. However, further progress may depend on novel approaches, focusing on other targets. This review will concentrate on those approaches which have already led to the initiation of clinical trials: agents designed to circumvent cellular drug resistance, signal transduction inhibitors, new hormonal agents, matrix metalloproteinase inhibitors, immunotherapy, immunotoxins and radioconjugates, and intraperitoneal genetic therapy, including the use of replicating viruses. In some cases, early clinical data are encouraging, but ultimately combined treatment with conventional agents may make most impact.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1008315603401
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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