Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    An analysis of behavioural mechanisms involved in the acquisition of amphetamine anorectic tolerance (1983)
    Springer
    Psychopharmacology 79 (1983), S. 58-66 
    Details
    ISSN: 1432-2072
    Keywords: Amphetamine anorexia ; Behavioural tolerance ; Food deprivation ; Conditioned taste aversion ; Operant/classical conditioning ; Behavioural augmentation of tolerance ; Compensatory conditioning ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Deprived rats given 2.5 mg/kg d-amphetamine before milk access developed anorectic tolerance. Rats given identical treatment after milk access did not exhibit tolerance in a subsequent test when the drug was given before milk access, nor did they subsequently acquire tolerance more rapidly than drug-naive animals. Manipulations of the amount of lab chow given to supplement milk intake did not affect the rate of development of tolerance, indicating that development of anorectic tolerance could not be explained in terms of increasing food deprivation or body weight loss as has often been suggested. The lack of tolerance in subjects drugged chronically after milk intake was shown not to be due to the development of a conditioned taste aversion in these animals. The possibility that tolerance was due to the acquisition of a classically conditioned compensatory response which attenuated drug effects was investigated. In one experiment the injection procedure was used as a potential conditioned stimulus. A series of placebo injections was given to tolerant rats in an attempt to extinguish any conditioned response, but this failed to attenuate tolerance. No compensatory hyperphagic response was seen after placebo injections. A further experiment was performed in which cues accompanying drug administration were made more salient by transferring animals to a distinct environment (noise, odour, light) after drug administration. Giving the drug subsequently in the home environment did not lead to the loss of tolerance predicted by the conditioning model, nor was there any evidence of hyperphagia in response to a placebo injection in the distinct environment. These results offer indirect support for a learning interpretation of amphetamine anorectic tolerance, but not one that involves classical conditioning of a compensatory response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00433017
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Behavioural tolerance to amphetamine and other psychostimulants: The case for considering behavioural mechanisms (1983)
    Springer
    Psychopharmacology 80 (1983), S. 287-307 
    Details
    ISSN: 1432-2072
    Keywords: Tolerance ; Sensitization ; Amphetamine ; Cocaine ; Anorexia ; Stimulant ; Operant conditioning ; Classical conditioning ; Animal studies ; Synaptic mechanisms ; Functional tolerance ; Dispositional tolerance ; Behavioural tolerance ; Reinforcement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An hypothesis is presented about the nature of behavioural tolerance in animals to stimulant drugs. It is suggested that, in many behavioural procedures, tolerance is due to behavioural adaptation to those drug effects which cause disruption of ongoing rewarded behaviour. This unitary hypothesis accounts for the available data on tolerance and cross-tolerance to stimulants more effectively than all of the other more conventional explanations which are based upon dispositional or functional concepts, the most common of which are described, evaluated, and found to be inadequate. Furthermore, it is suggested that attempts to explain tolerance in terms of changes in synaptic functioning are subject to very considerable problems of interpretation and that an analysis of behavioural mechanisms may be of greater value in understanding the process of behavioural tolerance. Evidence for the basic behavioural hypothesis is outlined in some detail, and a theoretical justification presented for its major assumptions. Operant studies of chronic stimulant effects on behaviour have often produced very complex patterns of data, considerable differences being reported both between subjects and between studies. A speculative model is presented which attempts to account for this pattern of data in tolerance studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432109
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...