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The management of chronic granulomatous disease (1993)

Fischer, A. ; Segal, A. W. ; Seger, R. ; [et al.]

Springer

European journal of pediatrics 152 (1993), S. 896-899

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ISSN: 1432-1076

Keywords: Neutrophil ; Inflammation ; Immunodeficiency ; Granuloma ; Chronic granulomatous disease ; Infection ; Antibiotics ; Interferon ; Therapy

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Chronic granulomatous disease (CGD) is a primary immunodeficiency disease which results from absence of the NADPH oxidase in the professional phagocytic cells [13] neutrophils, monocytes, macrophages and eosinophils. Deficiency of this oxidase renders the patient liable to infection by bacteria and fungi, and, as the name of the disease suggests, to chronic granulomatous inflammation. These patients present with a great variety of infections and other complications of their disease, which often tax the clinical and therapeutic skill of the doctors responsible for their care. Collectively we look after, or advise on the management of, over 100 of these subjects, and have developed experience in the diagnosis and management of the infections and other clinical problems they present. We thought that it might be timely to provide guidelines for their management based upon this experience. The numbers of patients are still relatively small, and the clinical presentations very varied, so it is immpossible to provide clear statistical proof of the veracity of this advice. It does, however, reflect the working practise of the physicians caring for many of these patients in Europe.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01957525

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Benchmark solutions for the incompressible Navier-Stokes equations in general co-ordinates on staggered grids (1993)

Oosterlee, C. W. ; Wesseling, P. ; Segal, A. ; [et al.]

Chichester : Wiley-Blackwell

International Journal for Numerical Methods in Fluids 17 (1993), S. 301-321

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ISSN: 0271-2091

Keywords: Benchmark solution ; Incompressible Navier-Stokes ; Staggered grid ; General co-ordinates ; Multigrid ; Engineering ; Engineering General

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

Notes: Benchmark problems are solved with the steady incompressible Navier-Stokes equations discretized with a finite volume method in general curvilinear co-ordinates on a staggered grid. The problems solved are skewed driven cavity problems, recently proposed as non-orthogonal grid benchmark problems. The system of discretized equations is solved efficiently with a non-linear multigrid algorithm, in which a robust line smoother is implemented. Furthermore, another benchmark problem is introduced and solved in which a 90° change in grid line direction occurs.

Additional Material: 17 Ill.