ISSN:
1432-069X
Keywords:
Cyclosporin A
;
Beta-adrenergic adenylate cyclase
;
Phosphodiesterase
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary It has been known that beta-adrenergic adenylate cyclase response is decreased in psoriatic-involved epidermis. Since the immunosuppressive agent, cyclosporin A, is reported to be effective on psoriasis clinically, the effect of cyclosporin A on beta-adrenergic adenylate cyclase response in pig skin was examined in vitro. Therapeutic serum levels of cyclosporin A (100–400 ng/ml) augmented the beta-adrenergic adenylate cyclase response of the epidermis. Highest levels of cyclosporin A (2–20 μg/ml) did not have any effect on its response. Both low K m and high K m cyclic AMP phosphodiesterases were not affected by cyclosporin A. Therefore, it is suggested that the clinical efficacy of cyclosporin A on psoriasis can be explained partially by its direct effect on the keratinocyte itself.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00417710
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