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  • Polymer and Materials Science  (5)
  • Analytical Chemistry and Spectroscopy  (2)
  • Biliary Excretion  (2)
  • 1
    Digitale Medien
    Digitale Medien
    Effect of nafenopin (SU-13, 437) on liver function (1975)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 290 (1975), S. 235-250 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Nafenopin ; Biliary Excretion ; Hepatic Uptake ; Hypolipidemic Agents ; Dibromosulphthalein
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Rats treated with the hypolipidemic agent, nafenopin (SU-13, 437) exhibit a higher plasma retention and a markedly reduced biliary excretion of organic anions, such as sulfobromophthalein (BSP) and its dibromo analog (DBSP), indocyaninegreen (ICG), succinylsulfathiazole (SST) and polar metabolites of bilirubin and the carcinogens 7, 12-dimethylbenzanthracene (DMBA) and 3,4-benz-pyrene (BP), despite an increase in liver mass and a profound choleresis. However, taurocholate is not affected in this manner, which supports the idea of a transport mechanism for taurocholate that differs from that of other organic anions. A pharmacokinetic study was made for DBSP in vivo. After nafenopin treatment, primary hepatic uptake (k12) and transport from liver into bile (k23) are reduced in vivo. Infusion studies indicate that biliary transport maximum (Tm) for DBSP is also decreased although the calculated hepatic storage (S) is only moderately affected. In the isolated perfused liver, hepatic clearance and biliary excretion of BSP are reduced by two-thirds. The time course of anion tranport inhibition and the hepato-biliary disposition of 14C-nafenopin suggest a direct effect of the drug. The extra liver mass induced by nafenopin appears to be hypo- or nonfunctional with respect to hepatic transport of organic anions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00510553
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  • 2
    Digitale Medien
    Digitale Medien
    Effect of nafenopin (SU-13,437) on liver function (1975)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 290 (1975), S. 221-234 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Biliary Excretion ; Choleresis ; Nafenopin Enterohepatic Circulation ; Pharmacokinetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Administration of nafenopin (SU-13-437) to male rats for two days leads to a doubling of bile production and a 50% increase in liver weight. These two effects have been shown not to be directly interrelated. A marked decrease in biliary bile salt concentration suggests that the bile salt independent flow is stimulated. The extra bile produced is probably of canalicular origin since bile to plasma concentration ratios of erythritol are unchanged. At least three polar metabolites of nafenopin have been observed in rat bile. Obervations in rats with partial biliary fistulas indicate that the drug and its metabolites undergo extensive enterohepatic circulation. Our studies support the view that much of the enhanced bile flow is associated with the presence of nafenopin and/or its metabolites within the hepatobiliary system. However, the response is too extensive to be explained merely by osmotic choleresis. Induced structural changes in the liver may also account for some of this effect.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00510552
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  • 3
    Digitale Medien
    Digitale Medien
    A therotical basis for the “solvent effect” (1978)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 1 (1978), S. 275-276 
    Details
    ISSN: 0935-6304
    Schlagwort(e): Gas Chromatography ; Capillary ; Splitless injection ; Theoretical basis for reconcetration by solvent effects ; Guidelines for an effective solvent effect, in literature citation ; Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jhrc.1240010513
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  • 4
    Digitale Medien
    Digitale Medien
    Kathodische Korrosion von Blei im Erdboden (1969)
    Weinheim [u.a.] : Wiley-Blackwell
    Materials and Corrosion/Werkstoffe und Korrosion 20 (1969), S. 578-583 
    Details
    ISSN: 0947-5117
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Maschinenbau
    Beschreibung / Inhaltsverzeichnis: Cathodic corrosion of lead in the soilCathodic corrosion of lead in the soil can be expected in exceptional cases only. The corrosion found on a particular lead cable could be simulated in the laboratory. It could be confirmed, that  -  probably by decomposition of primary lead hydride  -  metallic lead is deposited below layers of Ca and Mg compounds already at potentials below -1,7 V. A special switching method was developed to account for breakthrough polarisation.
    Notizen: Kathodische Korrosion von Blei im Boden ist grundsätzlich nur in Ausnahmefällen zu erwarten. Diese an einem Kabel gefundene Korrosion wurde im Laboratorium nachgebildet. Hierbei konnte bestätigt werden, daß unter Deckschichten aus Calcium- und Magnesiumverbindungen bei Potentialen schon unter -1,7 V metallisches, Blei abgeschieden wurde, wahrscheinlich durch Zersetzung von primär entstandenem Bleihydrid. Für derartige Untersuchungen wurde eine spezielle Schaltmethode entwickelt, bei welcher auch die Durchtrittspolarisation berücksichtigt wird.
    Zusätzliches Material: 8 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/maco.19690200704
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  • 5
    Digitale Medien
    Digitale Medien
    Kunststoffe im Automobilbau - Anwendung und Wiederverwertung (1991)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 22 (1991), S. 275-278 
    Details
    ISSN: 0933-5137
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Maschinenbau
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/mawe.19910220710
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  • 6
    Digitale Medien
    Digitale Medien
    Untersuchung von vinylpyridiniumverbindungen IV.III. I. MIELKE und H. RINGSDORF, Makromol. Chem. 142 (1970) 319. Polyreaktionen von 2-vinylpyridiniumsalzen (1971)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 149 (1971), S. 295-301 
    Details
    ISSN: 0025-116X
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Physik
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/macp.1971.021490124
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  • 7
    Digitale Medien
    Digitale Medien
    Gewässerschutz in der BASF AG, Ludwigshafen (1978)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 50 (1978), S. 510-518 
    Details
    ISSN: 0009-286X
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Waste water purification at BASF, Ludwigshafen/Rh. The manifold problems encountered in the field of waste water treatment in the chemical industry are considered, together with the tasks involved, possible solutions, and costs incurred, for the example of BASF AG in Ludwigshafen. This example is particularly interesting because it shows how the waste water problems of a chemical factory that has been in existence for over a centurvey could be solved in the course of a ten-year plan. Twenty years after the inception of this plan, costs and success can now be quantified.
    Zusätzliches Material: 13 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/cite.330500705
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  • 8
    Digitale Medien
    Digitale Medien
    Detection and measurement of hazardous gases. Heinemann Educational Books, London, and Exeter, New Hampshire, USA, 1981. £25.00. ISBN: 0-435-71030-3 (1982)
    New York, NY [u.a.] : Wiley-Blackwell
    Fire and Materials 6 (1982), S. i 
    Details
    ISSN: 0308-0501
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Architektur, Bauingenieurwesen, Vermessung , Maschinenbau
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/fam.810060112
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  • 9
    Digitale Medien
    Digitale Medien
    Mid- and low-frequency Raman spectra of stable and metastable crystalline states of the 4-n-alkyl-4′-cyanobiphenyl (n = 9, 11, 12) liquid crystals (1992)
    Chichester [u.a.] : Wiley-Blackwell
    Journal of Raman Spectroscopy 23 (1992), S. 633-636 
    Details
    ISSN: 0377-0486
    Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Physik
    Notizen: Metastable crystalline states of each of the title compounds were reproducibly generated by rapid low-temperature quenching of the corresponding liquids, as judged by the phonon-like appearance of their low-frequency Raman spectra (5-200 cm-1) and by a splitting of the mid-Raman (ca. 2220 cm-1) CN stretch. Their observed aspects of peak frequencies, peak multiplicities and band widths differ markedly from those of the corresponding spectra of the stable crystals. We propose that the solid metastable configurations consist of packings or stacks of immobilized smectic-like structures with significant long-range positional order within each, but with disordered director orientations between them.
    Zusätzliches Material: 2 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jrs.1250231111
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