ISSN:
1432-0827
Keywords:
Carboxyterminal propeptide Type I procollagen
;
Osteomalacia
;
Biochemical markers
;
Osteoblast function
;
Bone mineralization defect
;
Vitamin D therapy
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
,
Physics
Notes:
Abstract Carboxyterminal propeptide of type I procollagen (PICP) was measured in sera from 25 patients with osteomalacia due to privational vitamin D deficiency. The mean value of serum PICP was significantly raised in patients with osteomalacia compared with 40 normal subjects (mean±SD, 161±82 ng/ml and 113±31 ng/ml, respectively; P=0.01). The raised serum PICP reflected the accelerated bone turnover in this condition as did the elevated serum total alkaline phosphatase (ALP), but the variation in values of serum PICP noted in individual patients may reflect the different stages of osteomalacia. The normalization of serum PICP and ALP, indicating a healing process of the bone disorder, needed longer time of vitamin D and calcium therapy. In contrast, adjusted serum calcium and inorganic phosphate (IP) responded and normalized rapidly. Serum PICP and total ALP appeared to behave differently in the disease and in its response to vitamin D therapy suggesting that these two markers may represent different functions of osteoblasts in osteomalacia.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00297181
Permalink
