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Digitale Medien

Importance of the matrix and its chemical activation on the stability of immuno-adsorbents (1995)

Ubrich, N. ; Hubert, P. ; Dellacherie, E. ; [weitere]

Chicester [u.a.] : Wiley-Blackwell

Journal of Molecular Recognition 8 (1995), S. 111-115

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Details

ISSN: 0952-3499

Schlagwort(e): immunoadsorbent ; stability ; antibodies release ; therapeutic use ; apolipoprotein B ; Chemistry ; Biochemistry and Biotechnology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Medizin

Notizen: Various matrices were reacted with four different activation reagents, in order to prepare immuno-adsorbents for the selective removal of low-density lipoproteins from blood plasma of patients affected by hypercholesterolaemia. The resulting immuno-adsorbents were compared to that obtained earlier with cyanogen bromide activation, in terms of coupling yield, adsorption capacity and moreover stability towards the various chemical and biochemical conditions to which they are submitted during their handling. Tresyl chloride-activated Sepharose 6 Fast Flow turns out to afford optimal stability in the whole pH range tested.

Zusätzliches Material: 4 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/jmr.300080120

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