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  • Bacteriochlorophyll  (1)
  • Biochemistry and Biotechnology  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Comparative in vivo sensitizing efficacy of porphyrin and chlorin dimers joined with ester, ether, carbon-carbon or amide bonds (1996)
    Chicester [u.a.] : Wiley-Blackwell
    Journal of Molecular Recognition 9 (1996), S. 118-122 
    Details
    ISSN: 0952-3499
    Schlagwort(e): photosensitizers ; porphyrins ; chlorins ; pheophorbide-a ; purpurin-18 ; photodynamic therapy (PDT) ; anti-tumor activity ; skin phototoxicity ; laser ; preliminary screening ; Chemistry ; Biochemistry and Biotechnology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: The anti-cancer activity of dimers joined with ether, ester or carbon-carbon bonds by photodynamic therapy (PDT) was compared by using DBA/2 mice transplanted with SMT/F tumors. Dimers with ether and carbon-carbon linkages were found to be more effective than those linked with ester bonds. Variation of the substituents at peripheral positions made a significant difference in in vivo efficacy. Among the ether and carbon-carbon linked dimers, the divinyl analogs were found to be most effective. The preliminary in vivo results also suggest that the position(s) of the hydrophilic substituents in the molecules make a remarkable difference in photosensitizing activity. An unsymmetrical dimer with an amide linkage, obtained from 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a (HPPH) was found to be less effective than HPPH.
    Zusätzliches Material: 4 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Artikel (Nationallizenzen)
  • 2
    Digitale Medien
    Digitale Medien
    Preparation and crystal structure of methyl [12-acetyl-8-ethyl]-bacteriopheophorbide d. - A new bacteriochlorophyll derivative (1991)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1991 (1991), S. 871-874 
    Details
    ISSN: 0170-2041
    Schlagwort(e): Bacteriopheophorbide d, methyl [12-acetyl-8-ethyl]- ; Bacteriochlorophyll ; Chemistry ; Organic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: Reaction of methyl bacteriopheophorbide d 2 in tetrahydrofuran with sodium methoxide led to oxidation of the ethyl side chain at position 12 to afford an acetyl group. Experiments with 18O2 suggest a mechanism via abstraction of a proton and reaction of the secondary radical formed with molecular oxygen. The implications of this mechanism for the biosynthesis of the bacteriochlorophylls are discussed. The 12-acetyl compound 3 was investigated by X-ray crystallography.
    Zusätzliches Material: 2 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jlac.1991199101150
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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