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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Surveys in geophysics 17 (1996), S. 347-360 
    ISSN: 1573-0956
    Keywords: Ultrasonic waves ; Attenuation ; Velocity ; Microstructure ; Thermal cracking ; Local fluid flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract The frequency dependent mechanism of local fluid flow was found to be the decisive absorption and dispersion mechanism in fluid containing sandstones. In the ultrasonic frequency range local fluid flow and grain surface effects control the behaviour of highly porous and highly permeable rock if a pore fluid is present. Both mechanisms depend less on macroscopic rock parameters like porosity and permeability than essentially on microscopic parameters like crack size, crack density and grain contact properties. To demonstrate directly the important influence of the microstructure on the rock elastic and anelastic properties the microstructure of a sandstone was artificially changed by thermal cracking. The cracked rock exhibits a clearly changed behaviour at low uniaxial as well as at high hydrostatic pressure despite small changes of porosity and permeability. Fluid effects increase due to cracking. The experimental results are explained by means of a rock, model and local fluid flow. These results emphasize that it is the microstructure which controls the elastic and anelastic rock behaviour, even at high hydrostatic pressure.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1437-160X
    Keywords: Biomechanics ; Lysosomal elastase ; Proteoglycans ; Collagen ; Cartilage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Rheumatic joint destruction usually starts with the destabilisation of cartilage. Lysosomal elastase is a candidate effector of this process, since this enzyme is found at the site of cartilage erosion by rheumatoid synovial tissue. In order to prove this hypothesis we assessed the mechanical stability of cartilage during treatment by this enzyme in vitro. An indentation apparatus was used for this purpose and biochemical as well as microscopic techniques were used to supplement the results thus obtained. Our findings show that elastase irreversibly impairs the stability of cartilage by lysis of matrix proteoglycans without the help of additive enzymes. Collagen fragmentation played no significant role during elastase-induced destabilisation, while specific collagenase attacked the collagen network within the matrix only subsequent to the removal of proteoglycans. These findings suggest that elastase is a leading enzyme during proteolytic cartilage degradation. In addition polysulfonated glycosaminoglycan was found to reduce the mechanical effect of elastase on normal cartilage. It is therefore concluded that local inhibition of elastase promises therapeutic benefit during rheumatic cartilage degradation. Upon treatment of cartilage with elastase we observed this enzyme not only within the matrix under destruction but also bound to chondrocytes. These findings support the hypothesis that elastase plays a role on the matrix not only by direct degradation, but also by an indirect effect mediated through living chondrocytes.
    Type of Medium: Electronic Resource
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