ISSN:
1432-1076
Keywords:
Surfactant treatment
;
Preterm infants
;
Dopplerultrasound
;
Blood flow velocity
;
Internal carotid artery
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract As a part of a multicentre clinical trial of prophylattic treatment with bovine surfactant (SF-RI 1) given to immature infants below 31 gestational weeks, short term and protracted effects on cerebral haemodynamics were assessed by Dopplersonographic measurements of the right internal carotid artery. Measurements were performed every 10 min for 1h after intratracheal application of the surfactant in ten treated infants. The results of additional measurements every 12h up to the age of 100h were compared with a control group. In single cases there were changes of time averaged mean maximum velocity (Vmax) of as much as 100% immediately after intratracheal surfactant application, although the mean short term and protracted variability of Vmax was the same as the protracted variability in the control group. Variability of mean arterial blood pressure and transcutaneous carbondioxide tension (tcpCO2) was even less. With proper adjustment of ventilatory settings intratracheal treatment with surfactant does not affect variability or absolute values of internal carotid Vmax, mean arterial blood pressure and transcutaneous pCO2 in low birth weight infants within 100h after application.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00443108
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