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  • 1
    Electronic Resource
    Electronic Resource
    Clinical pathology of primitive gliomas in the cerebrum (1986)
    Springer
    Acta neurochirurgica 81 (1986), S. 94-99 
    Details
    ISSN: 0942-0940
    Keywords: Primitive glioma ; ependymoblastoma ; undifferentiated glioma ; unclassified glioma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To clarify the biological features of primitive gliomas in the cerebrum and clearly distinguish them from malignant or anaplastic gliomas and glioblastomas, we studied eight cases clinically and pathologically. Our evaluations included immunohistochemical and electron microscopic observations. We divided the patients into two groups, children and young adults. Most tumours appeared as ring-like, enhanced masses on computed tomography and avascular or ring-like, vascular masses on angiography. Macroscopically, the tumours were well demarcated and contained cysts. Ocassionally we found tumour dissemination. Microscopically, the tumours were composed of small, round cells without remarkable structural features. Ependymal, astroglial, and oligodendroglial differentiation was evident, in varying proportions; tumours in which the differentiated areas constituted more than half of the mass were classified as poorly differentiated gliomas. By these criteria, this series comprised four undifferentiated and four poorly differentiated gliomas. Cell anaplasia and polymorphism were rare in both undifferentiated and differentiated areas of the tumours. Immunohistochemical and electron microscopic examinations also revealed glial differentiation. These primitive gliomas appear to be biologically similar, but not identical, to cerebellar medulloblastomas. In this series, five patients died because of recurrence or dissemination. Whole brain and spinal irradiation should be considered after total or subtotal surgical removal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01401228
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Identification of fetal hemoglobin in blood stains by high performance liquid chromatography (1989)
    Springer
    International journal of legal medicine 102 (1989), S. 437-444 
    Details
    ISSN: 1437-1596
    Keywords: Fetal hemoglobin, identification in blood stains ; Blood stains, identification of fetal hemoglobin ; Fetales Hämoglobin, in Blutspuren ; Blutspuren, Nachweis von fetalem Hämoglobin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Es wurde eine neue Methode zur Identifizierung von fetalem Hämoglobin (Hb F) in Blutspuren mit der umgekehrten Phase-Hochleistungsflüssigkeitschromatographie durchgeführt. Die Unterscheidung zwischen fetalen Blutspuren und denen von Erwachsenen erfolgte aufgrund der Existenz der Spitzen der γ-Ketten von Hb F. In den Chromatogrammen der untersuchten Blutspuren von Erwachsenen traten fast keine γ-Ketten auf. Diese Methode ermöglichte ferner die Bestimmung des Hb F-Wertes mit dem Flächenverhältnis der Globin-Ketten auf den Chromatogrammen. Hb F-Werte der sechs Fälle von Nabelschnurblutspuren auf dem Filterpapier lagen zwischen 81.1% und 91.3%. Die vorliegende Untersuchung zeigt, daß sich der Hb F-Wert für mindestens 12 Wochen nicht ändert. In der Praxis der Rechtsmedizin ist diese Methode im Hinblick auf die Einfachheit, hohe Empfindlichkeit, Schnelligkeit und Zuverlässigkeit sehr wertvoll.
    Notes: Summary A new method for the identification of fetal hemoglobin (Hb F) in blood stains by reverse-phase high performance liquid chromatography is described. Differentiation between fetal and adult blood stains is based on the existence of γ-chain peaks which are characteristic of Hb F. Very few γ chains appeared on chromatograms of all the adult blood stains examined. The level of Hb F could be determined by measuring the total of chromatogram γ-globin chain areas, and expressing it as a percentage of total Hb. Levels in six cord blood stains on filter paper ranged from 81.1% to 91.3% and remained constant for at least 12 weeks. This method is of great value for its simplicity, sensitivity and speed, and most importantly for its reliability in the field of forensic medicine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00204074
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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