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Initial treatment of acute graft-versus-host disease with a murine monoclonal antibody directed to the human α/β T cell receptor (1991)

Beelen, Dietrich W. ; Grosse-Wilde, Hans ; Ryschka, Ursula ; [et al.]

Springer

Cancer immunology immunotherapy 34 (1991), S. 97-102

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ISSN: 1432-0851

Keywords: Bone marrow transplantation ; Acute graft-versus-host disease ; Monoclonal antibody

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary A murine IgG2b monoclonal antibody directed to the constant part of the human α/β T cell receptor (BMA031) was investigated in a pilot study as an initial treatment for acute graft-versus-host disease (aGvHD) after allogeneic bone marrow transplantation. The treatment protocol consisted of 5 mg BMA031 on 5 consecutive days with continuation of the prophylactic baseline immuno suppression using cyclosporin. Seven patients with grades II–III acute graft-versus-host disease were entered on the protocol and six patients completed the full treatment course. Mild to moderate acute adverse reactions to the first BMA031 infusion occurred in three patients. A nearly complete decline of circulating T lymphocytes was observed during BMA031 therapy, but the T cells returned to pretreatment values within 1 week after the last infusion. Serum pharmacokinetics of free antibody best fitted to a two-compartment open model with a mean initial half-life of 6 h and an estimated mean terminal half-life of 40 h. One patient developed antimurine antibodies of the IgM subclass. In five patients a complete and sustained resolution of all disease manifestations was attained, while in one patient a temporary response of skin involvement with aGvHD was noted. These results indicate that BMA031 can be safely administered as initial treatment of aGvHD. The therapeutic responses observed warrant its further clinical evaluation in this setting.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01741342

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Synthese eines 2H-Inden-2-on-Dianion-Komplexes durch Reduktion eines metallgebundenen Dicarbens (1993)

Öfele, Karl ; Dyckhoff, Florian ; Krist, Herbert G.

Weinheim : Wiley-Blackwell

Berichte der deutschen chemischen Gesellschaft 126 (1993), S. 2573-2578

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ISSN: 0009-2940

Keywords: Chelate dicarbenes ; Indenone ; Cyclovoltammetry ; Chemistry ; Inorganic Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: Synthesis of a 2H-Inden-2-one Complex by Reduction of a Metal-Bound DicarbeneHerrn Professor Dr. Dr. h. c. mult. E. O. Fischer zum 75. Geburtstag gewidmet.Tetracarbonylchromium complexes with chelating o-phenylene-biscarbene ligands are reduced in two steps as shown by cyclic voltammetry. The first step corresponds to a reversible one-electron transfer, the second to an irreversible one-electron reduction followed by a rapid rearrangement of the biscarbene ligand into an η5-bound 2H-inden-2-one system by a twofold C-C coupling with one CO ligand. By reaction of tetracarbonyl[o-phenylenebis(methoxymethylene)]chromium (4) with sodium amalgam in acetonitrile the diamagnetic tricarbonyl(η5-1,3-dimethoxy-2-indenone)chromium dianion [6]2- is formed as the final reduction product. Its structure was determined by NMR and IR spectroscopy.

Additional Material: 2 Ill.