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  • 1
    ISSN: 1432-0584
    Keywords: Knochenmarktransplantation ; Genetischer Marker ; Lymphozyten-Phosphoglukomutase ; Bone marrow transplantation ; Genetic marker ; Lymphocyte phosphoglucomutase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Lymphocyte phosphoglucomutase can be used as a genetic marker to document successful engraftment in bone marrow transplant recipients. Two patients who underwent marrow transplantation as a treatment for acute leukemia showed a change into donor-type isozyme pattern.
    Notes: Zusammenfassung Phosphoglukomutase aus Lymphozyten kann als genetischer Marker in der Knochenmarktransplantation verwendet werden. Nach Knochenmarktransplantation von zwei Patienten mit akuter Leukose konnte der Übergang in das Iso-Enzymmuster des Spenders beobachtet werden.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0584
    Keywords: Bone marrow transplantation ; Malignant lymphoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Allogeneic bone marrow transplantation from histocompatible sibling donors was performed in six patients with extranodal involvement of high grade lymphoma during first complete remission. Five patients had lymphoblastic lymphoma and one had diffuse undifferentiated lymphoma. The cytoreductive/immunosuppressive regimen consisted of total body irradiation and high dose cyclophosphamide. Four patients are alive in complete remission at 8 months, 14 months, 21 months and 47 months post transplantation. One patient who relapsed 7 months after his initial transplantation underwent a second transplantation but another relapse 17 months later led to his death. One patient died of chronic graft-versus-host disease and at autopsy there was no evidence of lymphoma. These data demonstrate that allogeneic bone marrow transplantation can produce durable remissions in patients with high grade lymphoma who present with bone marrow, central nervous system and/or skin involvement.
    Type of Medium: Electronic Resource
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