ISSN:
1432-1920
Keywords:
Key words Xenon CT
;
Astrocytoma
;
Brain-blood partition coefficient
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract It is possible to underestimate the grade of nonenhancing cerebral tumours on conventional contrast-enhanced MRI or CT. Differentiation of high- and low-grade gliomas by measurement of the brain-blood partition coefficient lambda (Tλ ) with Xe-enhanced CT (XeCT) has been reported. We assessed the practical applications of XeCT in suspected low-grade astrocytomas. We examined 15 patients with tumours which showed no contrast enhancement on conventional MRI and CT, using XeCT. Tumour blood flow (TBF) and Tλ were calculated. Fourteen patients underwent surgery, one patient had a biopsy. We recognised three histological groups. While Tλ differed significantly between them, TBF did not. Group 1 contained grade II–III astrocytomas and Tλ was 0.77; group 2 contained grade I–II astrocytomas with Tλ 1.14, and group 3 four oligodendrogliomas in which a Tλ of 1.50 was found.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002340050481
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