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  • 1995-1999  (2)
  • 74.72.Bk  (1)
  • C peptide  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Rat C peptide I and II stimulate glucose utilization in STZ-induced diabetic rats (1999)
    Springer
    Diabetologia 42 (1999), S. 958-964 
    Details
    ISSN: 1432-0428
    Schlagwort(e): Keywords Insulin action ; diabetes mellitus ; euglycaemic clamp ; C peptide ; nitric oxide.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Aims. To study the effects of physiological concentrations of rat proinsulin C peptide I and II, respectively, on whole body glucose utilization in streptozotocin diabetic and healthy rats. Methods. A sequential insulin clamp procedure was used (insulin infusion rates 3.0 and 30.0 mU · kg–1· min–1) in awake animals. C-peptide infusion rates were 0.05 and 0.5 nmol · kg–1· min–1. Blood glucose was clamped at 7.7 ± 0.3 mmol/l in the diabetic rats and at 3.9 ± 0.1 mmol/l in the healthy rats. Results. In diabetic rats infused at lower rates of C peptide and insulin, glucose utilization increased by 79–90 % (p 〈 0.001) compared with diabetic animals infused with saline and insulin. Increasing the rate of C-peptide infusion tenfold did not elicit a statistically significant further increase in glucose utilization. C peptide I and II exerted similar effects. The metabolic clearance rate for glucose in the diabetic animals infused with C peptide was not different from that of the healthy rats. During high-dose insulin infusion (30.0 mU · kg–1· min–1) glucose utilization increased considerably and no statistically significant C-peptide effects were observed. About 85 % of the increase in glucose utilization induced by C peptide could be blocked by treatment with N-monomethyl-l-arginine. Conclusions/interpretation. Physiological concentrations of homologous C peptide stimulate whole body glucose utilization in diabetic but not in healthy rats. C peptide I and II elicit similar effects. The influence of C peptide on glucose utilization may be mediated by nitric oxide. [Diabetologia (1999) 42: 958–964]
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s001250051254
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Zn-substitution effects on the normal optical conductivity and the superconducting gap (1996)
    Springer
    Journal of low temperature physics 105 (1996), S. 743-748 
    Details
    ISSN: 1573-7357
    Schlagwort(e): 74.72.Bk ; 74.25.Gz ; 74.62.Dh
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract The Zn-substitution effects on the c-axis optical spectra have been investigated for highly oxygenated YBa2 Cu3Oy crystals with y = 6.88 – 6.92. In the normal state, the Zn-substitution does not affect the high frequency conductivity but changes the ω-dependence of the scattering rate at low frequencies, leading to the increase in the dc resistivity in the c-direction. In the superconducting state, we observed a pronounced effect of Zn-substitution that a large number of unpaired carriers form a Drude-like absorption band within the gap, keeping the maximum gap amplitude unchanged. The missing area which gives the superfluid density is found to correlate with Tc.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00768472
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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