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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Diabetologia 12 (1976), S. 519-521 
    ISSN: 1432-0428
    Keywords: Glucagon-glucose infusion test ; synthetic human C-peptide ; C-peptide immunoreactivity (CPR) ; half time for CPR ; half time for IRI ; insulinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Glucagon (1 mg) and glucose (60 ml of 50% solution) were infused over 60 min to three normal and one obese subjects and two insulinoma patients. Plasma C-peptide immunoreactivity (CPR) and immunoreactive insulin (IRI) increased during the infusion. Half time of CPR after cessation of the infusion was 20.1±4.0 min, and that of IRI 9.8±1.3 min, respectively. This difference partly explains the higher molar concentration in plasma of CPR than IRI.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0428
    Keywords: Synthetic human connecting peptide ; C-peptide immunoreactivity (CPR) ; urine CPR ; blood CPR ; radioimmunoassay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A double-antibody radioimmunoassay method, using synthetic human connecting peptide as an immunizing antigen and standard, was evaluated for clinical assay of blood and urine samples. Normal fasting blood connecting peptide immunoreacivity (CPR) was 2.45±0.96 ng/ml, increasing promptly after a 50 g oral glucose load, but somewhat slower than insulin. Molar concentration of CPR exceeded that of insulin. CPR responses to glucose were subnormal in diabetics, very low in juvenile-type cases, and often poor in patients on insulin treatment. Fasting CPR levels were elevated in patients on corticosteroid treatment and with uraemia. A patient with insulin “auto-antibod” had high serum CPR. A considerable amount of CPR appeared in urine. Normal daily excretion of CPR was 1.52±0.55 μg/kg or 55.1±18.2 ng/mg creatinine. Urine CPR was very low in juvenile-type diabetics, and elevated in patients on corticosteroid treatment. The results confirm that blood and urine CPR are useful measures of the endocrine pancreatic function.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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