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Digitale Medien

Conformational studies of chemotactic HCO-Met-Leu-Phe-OMe analogues (1995)

Vertuani, G. ; Boggian, M. ; Breveglieri, A. ; [weitere]

Springer

Amino acids 9 (1995), S. 375-383

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Details

ISSN: 1438-2199

Schlagwort(e): Amino acids ; Chemotactic peptides ; Structure/activity relation-ship ; CD ; IR ; Conformation

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary In order to investigate the proper peptide backbone conformation able to elicit a biological activity, HCO-Met-Pro-Phe-OMe, HCO-Met-Ψ[COO]Leu-Phe-OMe, and HCO-Met-OLeu-Phe-OMe, analogues of the prototypical chemotactic peptide HCO-Met-Leu-Phe-OMe, were studied by CD and IR techniques. The results obtained comparing biological and conformational data evidence the critical presence of (i) the NH group at position 2, (ii) a rather flexible backbone, (iii) the chemical structure of the central residue which can affect the stability of a possible active conformer.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00807274

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