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  • 1
    Electronic Resource
    Electronic Resource
    Cd30-ligand and CD40-ligand expression in lymph nodes involved with Hodgkin's disease (1997)
    Springer
    Annals of oncology 8 (1997), S. 97-100 
    Details
    ISSN: 1569-8041
    Keywords: CD30L ; CD40L ; FasL ; Hodgkin's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Reed–Sternberg cells of Hodgkin's disease express CD30and CD40 receptors. The ligands for these receptors have been reported to have pleiotropic biologic activities in vitro, including induction of cell death. Expression of the ligands for these receptors in lymph nodes involved with Hodgkin's disease is not known. Purpose: The purpose of this study was to examine CD30 ligand (L) andCD40L expression in lymph nodes of patients with Hodgkin's disease, and to study CD30L expression on nodal lymphocyte subsets. Materials and methods: CD30L expression on subsets of lymphocytes of five lymph nodes involved with Hodgkin's disease was determined by two-color FACScan. Messenger RNA expression of CD30L and CD40L was determined by there verse-transcriptase polymerase chain reaction (RT-PCR) method performed on seven specimens involved with Hodgkin's disease (five lymph nodes and two spleens). Results: Four of seven specimens (57%) contained cells that expressed CD30L mRNA and three specimens (43%) containedCD40L-expressing cells. The mean percentage of nodal lymphocytes expressingCD30L surface protein was ≤20%. Conclusion: Hodgkin's disease lymph nodes and spleens frequently lackCD30L- and CD40L-expressing cells, and when CD30L is expressed, it is usually detected on few numbers of lymphocytes. The differences in the level of expression of these ligands in Hodgkin's disease lymph nodes may be related to the disease's clinical behavior.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008250820588
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Cd30-ligand and CD40-ligand expression in lymph nodes involved with Hodgkin's disease (1997)
    Springer
    Annals of oncology 8 (1997), S. 97-100 
    Details
    ISSN: 1569-8041
    Keywords: CD30L ; CD40L ; FasL ; Hodgkin's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Reed–Sternberg cells of Hodgkin's disease express CD30and CD40 receptors. The ligands for these receptors have been reported tohave pleiotropic biologic activities in vitro, including induction of celldeath. Expression of the ligands for these receptors in lymph nodes involvedwith Hodgkin's disease is not known. Purpose: The purpose of this study was to examine CD30 ligand (L) andCD40L expression in lymph nodes of patients with Hodgkin's disease, and tostudy CD30L expression on nodal lymphocyte subsets. Materials and methods: CD30L expression on subsets of lymphocytes of fivelymph nodes involved with Hodgkin's disease was determined by two-colorFACScan. Messenger RNA expression of CD30L and CD40L was determined by thereverse-transcriptase polymerase chain reaction (RT-PCR) method performed onseven specimens involved with Hodgkin's disease (five lymph nodes and twospleens). Results: Four of seven specimens (57%) contained cells thatexpressed CD30L mRNA and three specimens (43%) containedCD40L-expressing cells. The mean percentage of nodal lymphocytes expressingCD30L surface protein was ≤20%. Conclusion: Hodgkin's disease lymph nodes and spleens frequently lackCD30L- and CD40L-expressing cells, and when CD30L is expressed, it is usuallydetected on few numbers of lymphocytes. The differences in the level ofexpression of these ligands in Hodgkin's disease lymph nodes may be relatedto the disease's clinical behavior.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008250820588
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Study on the relationship between retention behavior and molecular structure parameters of substituted benzene derivatives in RPLC (1996)
    Springer
    Chromatographia 42 (1996), S. 43-48 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Substituted benzenes ; Solubility parameter ; Substituent constant
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A quantitative structure-retention model derived from the concept of hydrophobic substituent constant (π) and the total solubility parameter (δT) has been established. It has been used to predict successfully the retention behavior of a number of solutes on various columns in several different eluents. The experimental results indicate that the model can be employed for the prediction of retention of substituted benzenes in a large volume fraction range of mobile phase. In addition, the physical meaning of the sign and the influence of the coefficients of the model on the retention process had been discussed together with the dependence of these coefficients on the composition of mobile phase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02271054
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Chemiluminescence determination of tiopronin and its metabolite 2-mercaptopropionic acid in human urine by HPLC coupled with flow injection (1997)
    Springer
    Chromatographia 44 (1997), S. 31-36 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Chemiluminescence detection ; Tiopronin ; Thiols
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary In previous pharmacokinetic studies tiopronin, a drug used for effective treatment of cystinuria and rheumatoid arthritis, and its metabolite 2-mercaptopropionic acid were analysed by conventional liquid chromatography with pre- and post-column derivatization and UV detection. Now a novel HPLC-coupled chemiluminescence-flow-injection analysis (CL-FIA) method has been developed for the determination of tiopronin and 2-mercaptopropionic acid in urine. The method is based on chemiluminescence from a Ce(IV) oxidation system sensitized by quinine, as proposed earlier by this group, and flow-injection analysis. The method, which has the advantages of high sensitivity and selectivity, simple sample treatment and prompt production of results, has also been preliminarily adapted for pharmacokinetic study of tiopronin in urine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02466512
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    Paper (German National Licenses)
    Fulltext
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