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  • 1
    Electronic Resource
    Electronic Resource
    Effect of CGRP antagonist, alpha-CGRP 8-37, on acid secretion in the dog (1994)
    Springer
    Digestive diseases and sciences 39 (1994), S. 1405-1408 
    Details
    ISSN: 1573-2568
    Keywords: calcitonin gene-related peptide ; CGRP antagonist ; alpha-CGRP 8-37 ; gastric acid secretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The recently synthesized calcitonin gene-related peptide (CGRP) antagonist, human alpha-CGRP 8-37, was used to study its effects on gastric acid secretion. Four dogs with gastric fistula were used to measure the antagonist's physiologic effects in the stomach. All dogs received a bactopeptone dextrose meal (intragastric titration to pH 5.5) with either continuous CGRP 8-37 (1000 pmol/kg/hr) or saline (control). Additionally, intravenous bombesin (75–600 ng/kg/hr) and bethanecol (12.5–100 µg/kg/hr) was tested in the presence of the antagonist. Plasma gastrin levels also were measured via radioimmunoassay (RIA) in control and CGRP 8-37-stimulated animals. Gastric acid secretion increased by 100% with infusion of 1000 pmol/kg/hr CGRP 8-37 when compared to the control. Acid output increased 98% with both intravenous antagonist and 600 ng/kg/hr bombesin when compared to bombesin alone. However, no augmentation of acid secretion by CGRP 8-37 was shown with 25 µg/kg/hr bethanecol. RIA of plasma gastrin demonstrated no effect with the antagonist when given alone and did not increase bombesin-stimulated gastrin release. We conclude that CGRP 8-37 blocks native CGRP inhibitory effects on gastric acid secretion. Our findings of potentiation of acid secretion by bombesin as well as no change in gastrin levels in the presence of the antagonist is likely due to a blockage in a noncholinergic neuron to the somatostatin cell. Furthermore, CGRP 8-37 did not increase bethanecolstimulated acid secretion, most likely due to bethanecol's (acetylcholine) nearly ubiquitous positive effects on acid secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02088041
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Influence of tobacco leaf surface chemicals on germination ofPeronospora tabacina adam sporangia (1990)
    Springer
    Journal of chemical ecology 16 (1990), S. 1565-1576 
    Details
    ISSN: 1573-1561
    Keywords: Nicotiana ; Solanaceae ; Peronospora tabacina ; blue mold ; Alternaria alternata ; leaf surface chemistry ; diterpenes ; sucrose esters ; hydrocarbons ; spore germination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Chromatographic procedures were utilized to isolate and purify components of tobacco cuticular extracts and leaf surface chemicals.In vitro microbial bioassays determined the influence of these leaf surface compounds on germination and germ tube morphology ofP. tabacina sporangia, the tobacco blue mold pathogen, and to a lesser extentAlternaria alternata, the tobacco brown spot pathogen. Exposure to 10 μg/cm2 of α- and β-duvatrienemonols, sucrose esters, or hydrocarbons did not inhibit germination, whereas germination was significantly decreased bycis-abienol.cis-Abienol did not inhibit sporangial germination when combined with sucrose esters or hydrocarbons at a combined 10 μg/cm2. Germination of sporangia was completely inhibited by α- and β-duvatrienediols. In contrast to a previous report, α-DVT-diol was more inhibitory than the β isomer. Toxic effects of the DVT-diols were not altered by pH. Diluting the DVT-diols to less than 0.1 μg/cm2 resulted in a small but significant stimulation of germination. Previously, the DVT-diols had been identified only as inhibitory toP. tabacina. None of the leaf surface chemicals affected germination ofA. alternata conidia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01014090
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    Paper (German National Licenses)
    Fulltext
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