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  • 1
    Electronic Resource
    Electronic Resource
    Comparative effects of phenformin, metformin and glibenclamide on metabolic rhythms in maturity-onset diabetics (1977)
    Springer
    Diabetologia 13 (1977), S. 145-152 
    Details
    ISSN: 1432-0428
    Keywords: Phenformin ; metformin ; glibenclamide ; blood glucose ; lactate ; alanine ; pyruvate ; ketone bodies ; maturity-onset diabetes ; diabetic control ; gluconeogenesis ; glycerol ; insulin ; triglycerides ; growth hormone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twelve hour metabolic rhythms have been performed on six maturity-onset diabetic subjects during successive periods of therapy with phenformin, metformin, and glibenclamide. Moderate control of blood glucose concentration was achieved with phenformin and metformin, the lowest concentrations being found with glibenclamide. Mean blood lactate concentration was grossly elevated during phenformin therapy, moderately elevated with metformin and normal during glibenclamide treatment. Similar patterns were found for the lactate/pyruvate ratio, alanine, glycerol and ketone bodies. Serum triglyceride concentrations were significantly higher during phenformin treatment than with the other two regimes. Serum insulin concentration was higher on glibenclamide than with either biguanide. Most of these effects of the biguanides could be accounted for by an inhibitory effect on hepatic gluconeogenesis. It is concluded that the use of biguanides as hypoglycaemic agents in diabetes is associated with the production of multiple metabolic abnormalities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00745143
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Metabolic abnormalities during combined sulphonylurea and phenformin therapy in maturity-onset diabetics (1978)
    Springer
    Diabetologia 14 (1978), S. 389-395 
    Details
    ISSN: 1432-0428
    Keywords: Phenformin ; sulphonylureas ; blood glucose ; lactate ; pyruvate ; ketone bodies ; alanine ; glycerol ; non-esterified fatty acids ; growth hormone ; gluconeogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twelve hour metabolic rhythms have been determined in two groups of subjects during combined therapy with a sulphonylurea and phenformin 50 mg twice daily. Subjects with clinical evidence of complications of diabetes showed greater abnormalities in concentrations of blood intermediary metabolites than a group of subjects without complications despite similar mean blood glucose concentrations in the two groups (7.6 mmol/l with complications; 7.3 mmol/l without complications). Mean blood lactate (1.93 mmol/l v 1.39 mmol/l), alanine (0.56 mmol/1 v 0.43 mmol/l), total blood ketone bodies (0.20 mmol/l v 0.14 mmol/l) and several other intermediary metabolites and their ratios were significantly higher in the group with diabetic complications. It is suggested that the differences between the two groups may arise from impaired disposal of phenformin leading to higher blood concentrations in the group with diabetic complications, despite normal liver function tests and plasma creatinine concentration. It is probable that this accumulation of phenformin results in more pronounced effect upon blood glucose and other intermediary metabolites. Thus, the metabolic abnormalities previously reported in patients treated by phenformin alone are also present during combined sulphonylurea and phenformin therapy, and in the presence of diabetic microangiopathy these abnormalities are accentuated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01228133
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Cumene hydrogenation turnover rates on Mo2C: CO and O2 as probes of the active site (1999)
    Springer
    Catalysis letters 58 (1999), S. 169-171 
    Details
    ISSN: 1572-879X
    Keywords: molybdenum carbide ; turnover rates ; cumene hydrogenation ; CO and O2 chemisorption ; active site density
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The use of CO and O2 chemisorption to titrate surface sites on β-Mo2C was examined using cumene (isopropylbenzene) hydrogenation as a test reaction. The tests were carried out using β-Mo2C samples prepared at two different temperatures so as to deposit different amounts of pyrolytic carbon on their surfaces. Synthesis at 961 K produced a surface that was substantially free of pyrolytic carbon (90% clean), while synthesis at 981 K produced a surface that was contaminated with carbon (25% clean). It was found that O2 uptakes were about six times higher than CO uptakes, but both gave consistent turnover rates for the reaction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1019062925008
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    Paper (German National Licenses)
    Fulltext
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