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  • 1
    Electronic Resource
    Electronic Resource
    Influence of sodium chloride on the amount of CRF-granules and “classical” neurosecretory material (NSM) in the neurohypophysis of bilaterally adrenalectomized rats (1976)
    Springer
    Anatomy and embryology 149 (1976), S. 307-313 
    Details
    ISSN: 1432-0568
    Keywords: CRF-granules ; Sodium chloride ; Adrenalectomy ; Rat ; Histology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Bilaterally adrenalectomized female SPF Wistar rats were given tap water containing various concentrations of sodium chloride to drink ad lib. After a survival period of 14 days the animals were killed by perfusion-fixation. Their brains were removed, fixed in pieric acid formalin solution and embedded in Paraplast. Serial sections of median eminence and hypophysial posterior lobe were cut and stained with crotonaldehyde-fuchsine. In the stained sections the amount of CRF-granules visible in the external zone of the median eminence, and the amount of “classical” neurosecretory material (NSM) occuring in the internal zone of the median eminence and in the posterior lobe of the hypophysis were estimated. After administration of drinking solutions to which 0%–1% sodium chloride were added, the amount of CRF-granules increased with increasing NaCl uptake, whereas the amount of “classical” NSM was not changed. Application of tap water containing 2% NaCl led to a marked decrease in the amount of “classical” NSM but did only slightly impair the amount of CRF-granules. From the findings it is concluded that 1. following bilateral adrenalectomy administration of sodium chloride inhibits the secretion of CRF-granules; 2. CRF-granules and “classical” NSM, although histochemical identical, have different functional significances; 3. the mechanisms regulating the secretion of CRF-granules are different from those controlling the release of “classical” NSM.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315446
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Ipsilateral diminution of CRF-granules after unilateral hypothalamic lesions (1977)
    Springer
    Cell & tissue research 185 (1977), S. 215-229 
    Details
    ISSN: 1432-0878
    Keywords: CRF-granules ; Adrenalectomy ; Hypothalamic lesions ; Rat ; Histology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Axons terminating in the outer layer of the median eminence of rats contain light microscopically visible granules. The granules are assumed to represent a corticotropin-releasing factor and, therefore, are called CRF granules. To find out whether neurons containing CRF-granules originate and run together with the neurons of the hypothalamus-neural lobe system (HNS), the effect of unilateral lesions in the HNS on the amount and distribution of CRF-granules was studied in bilaterally adrenalectomized rats. HNS lesions prevented the adrenalectomy-induced increase in CRF granules on the side of the lesion. Lesions outside the HNS or sham lesions did not influence the amount and distribution of the granules. The findings suggest that CRF-granules are located in terminals of neurons whose perikarya are situated in magnocellular hypothalamic nuclei. It can also be concluded that the axons of these neurons run within the HNS and do not decussate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00220666
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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