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  • 1
    ISSN: 1590-3478
    Keywords: CSF ; Neurological diseases ; Macromolecules ; GABAA receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Campioni di liquido cefalo-rachidiano di pazienti analizzati per casi di sospette malattie neurologiche sono stati separati nella componente macromolecolare (Peso Molecolare 〉3000 Daltons) ed in quella delle piccole molecole (PM〈3000 Daltons). La c omponente macromolecolare è stata testata per la sua possibile interferenza con l'accumulo di36Cl−, stimolato dal GABA, in “microsacs” della corteccia cerebrale di ratto. Per molte patologie non è stata rilevata alcuna interferenza. Fanno eccezione i pochi (2) casi di morbo di Parkinson; in entrambi i casi vi è una chiara stimolazione dell'attività GABAergica. Quest' ultima indicazione sembra degna di ulteriori indagini.
    Notes: Abstract Cerebrospinal fluid (CSF) samples from patients undergoing lumbar puncture for suspected neurological diseases were fractioned into macromolecular (MW〉3000 Daltons) and small molecule components (MW〈3000 Daltons). The macromolecular component was tested for its interference with GABA stimulation of36Cl− accumulation in rat cerebral cortex microsacs. For many pathologies, no interference was apparent; an exception was two patients with Parkinson's disease in whom there were clear signs of stimulated GABA activity. This last result seems worthy of further investigation.
    Type of Medium: Electronic Resource
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