ISSN:
1432-0533
Keywords:
Lewy body
;
Lewy body-like hyaline inclusion
;
Ca2+/calmodulin-dependent protein kinase II
;
Parkinson's disease
;
Amyotrophic lateral sclerosis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Ca2+/calmodulin-dependent protein kinase II (CaM kinase II) is one of the predominant protein kinases in the brain. We found that CaM kinase II immunoreactivity was concentrated in the peripheral halos of Lewy bodies (LBs) in Parkinson's disease and Lewy body-like hyaline inclusions (LBHIs) in amyotrophic lateral sclerosis. An immunoelectron microscopic examination of LBs revealed that the filaments at the periphery of LBs were decorated with immunopositive deposits. Since CaM kinase II has a broad substrate specificity and can phosphorylate neurofilaments and other cytoskeletal proteins, it may play some role in the formation of LBs and LBHIs through the aberrant phosphorylation of the cytoskeletal elements in these inclusions.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00294440
Permalink
