ISSN:
1617-4623
Keywords:
Caenorhabditis elegans
;
unc-26
;
Intragenic mapping
;
Lethal mutations
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary The genetic organization of unc-26(IV) and adjacent regions was studied in Caenorhabditis elegans. We constructed a fine structure genetic map of unc-26(IV), a gene that affects locomotion and pharyngeal muscle movement but not muscle structure. Eleven alleles were positioned relative to each other recombinationally and were classified according to phenotypic severity. The unc-26 gene spans at least 0.026 map units, which is exceptionally large for a C. elegans gene. All but one allele, e205, are amorphic alleles. Interestingly, e205 is hypomorphic but also suppressible by the amber suppressor sup-7. Nineteen lethal mutations in the unc-26 region were isolated and characterized. The unc-26 region is subdivided into four zones by five deficiency breakpoints. These mutations fall into 15 complementation groups. The stages of development affected by these mutations were determined.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00259412
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