Bibliothek

X
feed icon rss

Ihre E-Mail wurde erfolgreich gesendet. Bitte prüfen Sie Ihren Maileingang.

Leider ist ein Fehler beim E-Mail-Versand aufgetreten. Bitte versuchen Sie es erneut.

Vorgang fortführen?

Exportieren
  • 1
    Digitale Medien
    Digitale Medien
    Cloning and modulation by endothelin-1 of rat cardiac K channel
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 184 (1992), S. 1484-1489 
    Details
    ISSN: 0006-291X
    Schlagwort(e): [abr] 4-AP; 4-aminopyridine ; [abr] 8-Br-cAMP; 8bromoadenosine 3',5'-cyclic monophosphate ; [abr] CHO; Chinese hamster ovary ; [abr] TEA; tetraethylammonium chloride
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie , Chemie und Pharmazie , Physik
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1016/S0006-291X(05)80050-6
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 2
    Digitale Medien
    Digitale Medien
    Cloning and modulation by endothelin-1 of rat cardiac K channel
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 184 (1992), S. 1484-1489 
    Details
    ISSN: 0006-291X
    Schlagwort(e): [abr] 4-AP; 4-aminopyridine ; [abr] 8-Br-cAMP; 8bromoadenosine 3',5'-cyclic monophosphate ; [abr] CHO; Chinese hamster ovary ; [abr] TEA; tetraethylammonium chloride
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie , Chemie und Pharmazie , Physik
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1016/S0006-291X(05)80050-6
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 3
    Digitale Medien
    Digitale Medien
    Effects of calcium-antagonistic coronary vasodilators, nifedipine and verapamil, on ventricular automaticity of the dog (1978)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 302 (1978), S. 235-238 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Nifedipine ; Verapamil ; Calcium ; Ventricular automaticity ; Papillary muscle
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In isolated, blood-perfused canine papillary muscles intra-arterial injection of calcium-antagonistic coronary vasodilators, nifedipine and verapamil, produced a dose-related decrease in force of contraction. The ventricular rate of about 40 beats/min was not significantly changed by nifedipine even in doses which profoundly decreased the force of contraction. Verapamil changed the ventricular rate in a biphasic manner, but the changes remained as small as about 10% of the basal rate in doses which markedly suppressed the force of contration. Calcium chloride elicited an increase in force of contraction but depressed automaticity. The present results show that in response to nifedipine, verapamil and calcium ions, ventricular automaticity has characteristics different from those of the sinus node.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00517990
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 4
    Digitale Medien
    Digitale Medien
    Positive inotropic effect of 4-aminopyridine on dog ventricular muscle (1979)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 307 (1979), S. 207-212 
    Details
    ISSN: 1432-1912
    Schlagwort(e): 4-Aminopyridine ; Cardiac muscle ; Relaxation ; Action potential ; Catecholamines ; Calcium
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary 1. In trabecular muscles obtained from the right ventricle of untreated dogs 4-aminopyridine (4-AP) (0.1–10 mM) increased the force of contraction elicited by electrical driving at 0.5 Hz. 2. This effect was associated with increases in mean velocities of force development and relaxation. The time to peak force was not changed by 4-AP and the relaxation time was increased by 3 and 10 mM 4-AP. 3. In ventricular muscles treated with the β-adrenoceptor blocking agent, pindolol, or in those obtained from dogs pretreated with reserpine the positive inotropic effect was reduced. 4. In such muscles 4-AP scarcely increased the mean velocity of force development and slightly increased the time to peak force. Marked prolongation of the relaxation time and a decrease in mean velocity of relaxation were characteristic of isometric contractions of such muscles in the presence of 4-AP. 5. These results indicate that the positive inotropic effect of 4-AP is sum of two effects, one being due to the release of endogenous catecholamines and the other to a possible direct action on cardiac muscle. 6. In muscles treated with pindolol or those obtained from dogs pretreated with reserpine 10 mM 4-AP elevated the resting force. 7. These observations suggest that 4-AP causes a persisting elevation of cytosolic Ca2+ in cardiac muscle cells. 8. In pindolol-treated muscles 4-AP prolonged the action potential duration. However, the prolongation of the action potential duration produced by 4-AP was much smaller than that of the relaxation time. Even with 10 mM 4-AP the resting membrane potential remained unchanged. 9. The above results suggest that the effects of 4-AP on the contraction and resting force of ventricular muscle may not be secondary to the effect on the transmembrane potential. 10. All the results taken together suggest that the primary action of 4-AP on ventricular muscle may not be to allow increased or prolonged entry of extracellular Ca2+ but rather may be either to promote the release of Ca2+ from intracellular binding or storage sites or to slow the binding of Ca2+ to intracellular structures. The prolongation of the action potential duration may be a consequence of change in calcium binding to the plasma membrane.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00505935
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
Schließen ⊗
Diese Webseite nutzt Cookies und das Analyse-Tool Matomo. Weitere Informationen finden Sie hier...