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  • 1
    Digitale Medien
    Digitale Medien
    Cyclic AMP-dependent protein kinase in calf-snout epidermis (1986)
    Springer
    Archives of dermatological research 278 (1986), S. 367-371 
    Details
    ISSN: 1432-069X
    Schlagwort(e): Protein phosphorylation ; Cyclic AMP ; Cyclic AMP-dependent protein kinase ; Keratin polypeptide ; Calf-snout epidermis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The biochemical characteristics of cyclic AMP-dependent protein kinase in calf-snout epidermis were investigated. The activity of cyclic AMP-dependent protein kinase was higher in the lower layer than the upper layer of epidermis. The supernatant of homogenates of the lower layer of calf-snout epidermis was fractionated by DEAE-cellulose chromatography and contained two major peaks of protein kinase activity stimulated by cyclic AMP. This chromtographic pattern is similar to that referred to as Type I and Type II of cyclic AMP-dependent protein kinase in bovine muscle. Both peaks of cyclic AMP-dependent protein kinase in calf-snout epidermis could phosphorylate keratin polypeptides in vitro. The phosphorylation reaction was activated by cyclic AMP and inhibited by a heat-stable inhibitor of cyclic AMP-dependent protein kinase. When Type II enzyme of cyclic AMP-dependent protein kinase was incubated with [γ-32P]ATP in the absence of substrates, such as histone or keratin polypeptides, the 54,000 dalton protein was phosphorylated and this autophosphorylation was inhibited by the addition of 10 μM cyclic AMP. These results suggest that cyclic AMP-dependent protein kinase in calf-snout epidermis has properties similar to those in bovine muscle and plays an important role in the phosphorylation of keratin polypeptides in calf-snout epidermis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00418164
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Bromperidol, a new butyrophenone neuroleptic: A review (1982)
    Springer
    Psychopharmacology 78 (1982), S. 1-7 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Bromperidol ; Haloperidol ; Chlorpromazine ; Preclinical review ; Animal pharmacology ; Animal pharmacokinetics ; Animal biotransformation ; Animal drug safety
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract This review compares and contrasts the preclinical pharmacology of bromperidol with another butyrophenone neuroleptic, haloperidol, and the phenothiazine neuroleptic chlorpromazine. Its pharmacokinetics, biotransformation, and safety in several laboratory animal species are also summarized. These preclinical data support its use as an antipsychotic agent and show that it is well absorbed following oral administration with an apparent elimination half-life of approximately 24 h, supporting a once-daily dose regimen. Animal toxicity (including acute- and multiple-dose toxicology and reproductive and mutagenicity studies) show that bromperidol is well tolerated.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00470578
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