ISSN:
1420-9071
Keywords:
Calpain
;
calcium-activated neutral proteinase
;
spermine
;
spermidine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary The muscle enzyme calpain II, in contrast to muscle calpain I, was markedly inhibited by millimolar concentrations of the polyamines spermine and spermidine. These compounds and the calpain inhibitor calpastatin had synergistic inhibitory effects on calpain II. These results suggest that the polyamines may have possible regulatory effects on the in vivo activity of calpain II enzymes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01951764
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