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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    FEBS Letters 285 (1991), S. 225-229 
    ISSN: 0014-5793
    Keywords: Ca^2^+ pump ; Ca^2^+ release channel ; Ca^2^+ storage protein ; Calsiosome ; Endoplasmic reticulum ; Sarcoplasmic reticulum
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European archives of psychiatry and clinical neuroscience 228 (1980), S. 91-94 
    ISSN: 1433-8491
    Keywords: Phenytoin toxicity ; Anticonvulsant long-term therapy ; Folic acid ; Competitive protein-binding assay ; Hydantoin-Nebenwirkungen ; Antikonvulsive Langzeitbehandlung ; Folsäure ; Kompetitive Protein-Bindungs-Analyse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei einem Vergleich der mit Hilfe der kompetitiven Protein-Bindungs-Analyse gemessenen Werte der unreduzierten Folsäure im Serum zwischen 48 mit Hydantoin behandelten Epileptikern und 38 Normalpersonen ergab sich kein signifikanter Unterschied der Mittelwerte. Durchschnittlich lag der Folsäurespiegel bei den Epileptikern mit 7,73 nmol/l gegenüber 7,18 nmol/l bei den Kontrollpersonen etwas höher. Dieser Befund stützt die Hypothese, daß der Folatmangel bei Epileptikern auf einer Blockierung der Umwandlung von Folsäure in 5-Methyltetrahydrofolsäure durch Diphenylhydantoin beruht.
    Notes: Summary No significant difference was found in a comparison between the values of unreduced serum folic acid of 48 epileptics treated with hydantoin and 38 controls as measured by a competitive protein-binding assay. The average folic acid value was 7.73 nmol/l in the epileptics, a little higher than the 7.18 nmol/l found in the controls. This result supports the hypothesis that the folate deficiency in epileptics is caused by blocking the conversion of folic acid to 5-methyltetrahydrofolic acid by phenytoin.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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