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  • 1
    ISSN: 1432-1335
    Keywords: Indomethacin ; Prostaglandin E2 ; N-nitrosomethylurea ; Rat large bowel cancer ; Cancer prevention
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Nonsteroid antiinflammatory drugs such as indomethacin may play an important role in preventing the development of chemically induced experimental carcinomas of various organs including the large bowel in rats and mice. This effect might correlate with an inhibition of prostaglandin (PG) synthesis by these drugs. Sprague-Dawley rats were given three intrarectal doses of 4 mg N-nitrosomethyl-urea (MNU) within week 1 to induce large-bowel carcinomas. The experimental groups of rats received a 0.001% aqueous solution of indomethacin ad libitum as drinking water for days 1–8 and/or a subcutaneous injection of 500 μg/kg body weight of PGE2 immediately before and 2 h after each MNU dose. They were then maintained on basal diet and plain tap water without further treatment. At autopsy at week 31, the tumor incidence and the mean number of tumors per rat were 90% and 1.7 in untreated rats, 67% and 0.8 in indomethacin-treated rats, and 79% and 1.2 in indomethacin+PGE2-treated rats, respectively. The data indicate that indomethacin reduced the number of large-bowel tumors, while pharmacologic doses of PGE2 failed to reestablish the anticarcinogenic activity of indomethacin. It was concluded that a tolerable therapeutic dose of indomethacin can reduce the carcinogenic activity of MNU in the large bowel.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 339 (1975), S. 41-53 
    ISSN: 1435-2451
    Keywords: Cancer prevention ; Chemotherapeutic models ; Tasks of oncology ; Krebsprävention ; Chemotherapeutische Modelle ; Aufgaben der Onkologie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Als besonders vordringliche Aufgaben praxisnaher Krebsforschung werden herausgestellt 1. der multidisciplinäre Charakter der Onkologie, 2. die Notwendigkeit, mehr als bisher den krebskranken Menschen in den Mittelpunkt der Forschung zu stellen, 3. die Notwendigkeit, mit modernen Methoden der Genetik den Begriff der Disposition naturwissenschaftlich zu fassen, 4. Untersuchungen auf dem Gebiet der chemischen Carcinogenese zu intensivieren, da sich auf diesem Sektor am wahrscheinlichsten eine Prävention von Krebserkrankungen erreichen läßt und 5. die Erarbeitung praxisnaher experimenteller Modelle zum Studium chemotherapeutischer Möglichkeiten.
    Notes: Summary Particularly urgent tasks for practical cancer research are pointed out: (1) recognition of the multidisciplinary character of oncology, (2) placement of the cancer patient more than before in the focus of research, (3) the use of modern methods of genetics to specify the definition of a "disposition", (4) the intensification of investigations into the field of chemical carcinogenesis, since prevention of cancer diseases seems most likely in this sector, and (5) elaboration of practical experimental models for the study of chemotherapeutic possibilities.
    Type of Medium: Electronic Resource
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