ISSN:
1432-2307
Keywords:
Candidiasis
;
Secretory proteinase
;
Immunofluorescence
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The secretory aspartic proteinases ofCandida albicans andC. tropicalis are potential factors for virulence produced during infection. By indirect immunofluorescence, we have demonstrated proteinase antigen on elements of both species in deparaffinized tissue sections derived from clinical cases of mucosal and deep-seated candidiasis. Occasionally, we observed a halo of fluorescence in the close vicinity of candidal cells, which may reflect secretion of the enzyme. In kidneys, a ring of amorphous fluorescent material surrounding candidal colonies may illustrate alkaline denaturation of secreted enzyme within a pH gradient, which is generated by the fungus. Our findings support the view that candidal proteinase may be a diagnostically relevant antigen.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01626348
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