ISSN:
1040-0397
Keywords:
Copper electrode
;
Antibiotics
;
Capillary electrophoresis
;
Aminoglycosides
;
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Aminoglycoside antibiotics including gentamicin, bekanamycin, tobramycin, lincomycin, neomycin, kanamycin, and ribostamycin have been determined by CE-EC with copper clectrodes. Both copper wall-jet electrodes (WJEs) and copper on-capillary electrodes (OCEs) were evaluated. The OCEs provided μM detection limits, superior stability and reproducibility (2-3% relative standard deviation in oxidation current), and a simple instrumental set-up without the need for capillary/electrode alignment. The analytical capabilities of the Cu-OCE were examined, following the optimization of CE conditions, for the seven aminoglycosides above; and the practical utility of this approach was demonstrated through the determination of aminoglycoside antibiotics in three pharmaceutical preparations.
Additional Material:
6 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/elan.1140091502
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