ISSN:
1432-1335
Keywords:
Metabolism
;
Carcinogenicity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The objective of this study was to compare urinary metabolism of parent 3,3-dimethyl-1-phenyltriazene with that of its ring-substituted 1-(4-chlorophenyl)-3,3-dimethyltriazene and 1-(2,4,6-trichlorophenyl)-3,3-dimethyltriazene congeners, in an attempt to evaluate the molecular requirements for systemic carcinogenic activity. Complementary carcinogenicity assays were conducted at low equimolar dose levels using both 4- und 2,4,6-chlorinated and brominated analogues. Ring halogenation was found to prolong metabolic detoxification and to reduce carcinogenic activity.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00390976
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