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Digitale Medien

Calcium-induced calcium release activates contraction in intact cardiac cells (1989)

Valdeolmillos, M. ; O'Neill, S. C. ; Smith, G. L. ; [weitere]

Springer

Pflügers Archiv 413 (1989), S. 676-678

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Details

ISSN: 1432-2013

Schlagwort(e): Cardiac myocyte ; contraction ; sarcoplasmic reticulum ; caged Ca

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract The “caged” calcium chelator Nitr-5 was Incorporated into isolated rat ventricular myocytes. Brief illumination with ultra-violet light made the cell twitch. The light-induced twitch was inhibited by ryanodine (1–10 μM) suggesting that it resulted from calcium-induced release of calcium from the sarcoplasmic reticulum. Inhibition of the Ca current (Ni, 10 mM) abolished the electrically stimulated twitch but did not inhibit the light-induced twitch. These results provide direct evidence for the importance of Ca-induced Ca release in excitation-contraction coupling in the heart.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00581820

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