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  • Autosomal dominant transmission  (1)
  • Cardiopulmonary bypass  (1)
  • 1
    ISSN: 1432-1971
    Schlagwort(e): Open heart surgery ; Children ; Congenital heart disease ; Jehovah's Witnesses ; Hemodilution ; Cardiopulmonary bypass
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Between January 1979 and July 1989, 15 children of Jehovah's Witnesses underwent corrective open surgery for congenital heart disease (CHD) on cardiopulmonary bypass (CPB). Ages ranged from 1.5–17 years and body weight from 9.1–63 kg, with five patients weighing less than 15 kg. Eight children were cyanotic, and two of them had had previous thoracic operations. All operations were performed in moderate to deep hypothermia using a modified version of isovolemic hemodilution with bloodless priming technique of extracorporeal circulation. Mean hematocrit levels decreased from 47.3% (36.9–70%) to 34.6% (27.2–49.1%) after hemodilution, and then to 17.9% (10.5–25.6%) during bypass. They increased again to 34.1% (24.4–50%) at the end of the operation and to 33.4% (25.1–40%) on day 12. All intra- and postoperative hematocrit levels were significantly lower (p〈0.001). There was one postoperative death, not related to the technique. Our results demonstrate that bloodless cardiac surgery on bypass is feasible in children as shown in this special group of children of Jehovah's Witnesses. Knowing the risks of homologous blood transfusion this technique should be used more extensively in the future.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Pediatric cardiology 6 (1986), S. 227-229 
    ISSN: 1432-1971
    Schlagwort(e): Supravalvar aortic stenosis ; Aortic aneurysms ; Defect of elastic fibers ; Autosomal dominant transmission
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In a male patient with supravalvar aortic stenosis (SAS) and peripheral pulmonary arterial stenoses, aortic aneurysms developed between his first and fourth years of life. He died five days after correction of SAS and resection of aneurysms. Histologic examination revealed disarrangement as well as severe degeneration of elastic fibers in the aortic wall. This tissue defect is probably inherited through an autosomal dominant mechanism. It may lead to aneurysm formation. Only one case of SAS with aortic aneurysm has been previously reported.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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