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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nutrition 27 (1988), S. 229-235 
    ISSN: 1436-6215
    Keywords: growth hormone ; casein ; soy protein ; endocrine response ; hypercholesterolemia ; Wachstumshormon ; Casein ; Sojaprotein ; endokrine Reaktion ; Hypercholesterinämie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Description / Table of Contents: Zusammenfassung Casein, im Gegensatz zu pflanzlichen Proteinen, führt bei einigen Tierspezies zu Hypercholesterinämie. Dies könnte mit einer Änderung des Hormonstatus einhergehen. Neben anderen Hormonen hat das Wachstumshormon (GH) eine wichtige Rolle in der Regulation des Cholesterinstoffwechsels. Ein GH-Mangel führt zu Hypercholesterinämie. Diese Untersuchung zeigt, daß die zyklischen Schwankungen der GH-Spiegel durch die Art des Nahrungsproteins beeinflußt werden. Die GH-Mittelwerte und die errechnete Fläche unter den GH-Spiegeln über 4 Stunden sind bei Caseingefütterten Tieren höher als bei Sojaprotein-gefütterten Tieren. Höhere GH-Spiegel in Casein-gefütterten im Vergleich zu Gluten-gefütterten Tieren wurden bereits beobachtet. Unsere Daten unterstützen also die These, daß verschiedene Nahrungsproteine zu unterschiedlichen endokrinen Antworten führen. Da aber niedrige GH-Spiegel die Voraussetzung für die Ausbildung einer Hypercholesterinämie sind, können die beobachteten Unterschiede nicht die Basis für die Ausprägung einer Casein-induzierten Hypercholesterinämie sein.
    Notes: Summary Dietary casein, compared to vegetable protein, causes hypercholesterolemia in some animal species. This may be associated with a change of hormonal status. Among others, GH has an important impact on cholesterol metabolism; GH deficiency results in hypercholesterolemia. This paper shows that the rhythmic variation of GH levels in rats is differently affected by different dietary proteins. Within a 4-h observation period overall mean values and integrated areas under the GH levels plotted against time are higher with casein as compared to soy protein. Secretory GH peak values are lower than reported before for chow-fed rats. These observations support the idea that different dietary proteins cause a different endocrine response. As GH levels are higher with casein, while lower levels would be expected to be associated with hypercholesterolemia, the observed differences are obviously of less relevance for the expression of casein-induced hypercholesterolemia.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 66 (1988), S. 135-143 
    ISSN: 1432-1440
    Keywords: Serum cholesterol ; Nutrition ; Dietary protein ; Thyroxine ; Mechanism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Different dietary proteins determine different serum cholesterol levels if fed in a semisynthetic diet to some, but not all, animal species. In one species, the rabbit, this metabolic response is elicited without adding high sucrose or cholesterol supplements that have to be added to rat or pig diets in order to cause a similar response. Eleven out of 13 studies show that casein and soy protein do not induce different serum cholesterol levels in normal man. More important, protein-induced differences of serum cholesterol concentrations have not been reported when appropriate nutritional methodology has been applied. We conclude that no protein-induced hypercholesterolemia is observed in primates, particularly not in the human species. Dietary recommendations urging the general public to reduce consumption of animal protein because of a higher atherogenicity are not supported by the present data. The biochemical basis of the metabolic responses has been studied by many investigators, but no convincing unifying concept has yet been identified. The recent observation of higher serum thyroxine concentrations following soy protein consumption (and vegetable protein in general) when compared to casein shed new light on this problem. This endocrine response explains a wide array of metabolic features of soy-fed rodents: the lower hepatic VLDL secretion, the higher hepatic HMG-CoA reductase activity, the higher hepatic apo B, E receptor activity, the higher fecal bile acid excretion, and finally the lower serum cholesterol concentrations.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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