Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Evidence for separate neuronal mechanisms for the discriminative stimulus and catalepsy induced by Δ9-THC in the rat (1992)
    Springer
    Psychopharmacology 107 (1992), S. 117-124 
    Details
    ISSN: 1432-2072
    Keywords: Discriminative stimulus ; Catalepsy ; Marijuana ; Δ9-Tetrahydrocannabinol ; Opiate ; Neuroleptic ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The cataleptogenic effect of Δ9-THC was compared to its discriminative stimulus effects in rats. The ED50s for the discriminative stimulus and catalepsy were 0.8 and 4.0 mg/kg, respectively, while their time courses were very similar. The ED50 of Δ9-THC for catalepsy in experimentally naive rats was not different from that in rats trained with the drug discrimination procedure, indicating that the cataleptogenic effect was not appreciably attenuated by long-term exposure to low doses of Δ9-THC. Pharmacologically, the catalepsy produced by Δ9-THC more closely resembled that of haloperidol than of morphine, since anticholinergic pretreatment eliminated the Δ9-THC-induced catalepsy while pre-treatment with naloxone had no effect. Although the cataleptogenic effect of Δ9-THC could be pharmacologically manipulated by anticholinergic pre-treatment, its discriminative stimulus effects were not changed in the same animals. These results demonstrate that distinctive mechanisms of action exist for these cannabinoid-induced behaviors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02244975
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Systemic or intrahippocampal cannabinoid administration impairs spatial memory in rats (1995)
    Springer
    Psychopharmacology 119 (1995), S. 282-290 
    Details
    ISSN: 1432-2072
    Keywords: Radial-arm maze ; Δ9-tetrahydrocannabinol (Δ9-THC) ; CP-55,940 ; WIN-55,212-2 ; Anandamide ; Cannabidiol ; Hippocampus ; Antinociception ; Catalepsy ; Rectal temperature
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The purpose of the present study was to investigate the disruptive effects of cannabinoids on working memory as assessed in the eight-arm radial-maze. Systemic administration of Δ9-THC, WIN-55,212-2, and CP-55,940 increased the number of errors committed in the radial-maze. CP-55,940 was the most potent cannabinoid in impairing memory (ED50=0.13 mg/kg). Δ9-THC and WIN-55,212-2 disrupted mazechoice accuracy at equipotent doses (ED50 values =2.1 and 2.2 mg/kg, respectively). In addition, systemic administration of each of these agents retarded completion time. Whereas the doses of Δ9-THC and CP-55,940 required to retard maze performance were higher than those needed to increase error numbers, WIN-55,212-2 was equipotent in both of these measures. On the other hand, neither anandamide, the putative endogenous cannabinoid ligand, nor cannabidiol, an inactive naturally occurring cannabinoid, had any apparent effects on memory. A second aim of this study was to elucidate the neuroanatomical substrates mediating the disruptive effects of cannabinoids on memory. Intrahippocampal injections of CP-55,940 impaired maze performance in a dose-dependent manner (ED50=8 µg/rat), but did not retard the amount of time required to complete the maze. The effects of intrahippocampal CP-55,940 were apparently specific to cognition because no other cannabinoid pharmacological effects (e.g., antinociception, hypothermia, and catalepsy) were detected. This dissociation between choice accuracy in the radial-maze and other cannabinoid pharmacological effects suggests that the working memory deficits produced by cannabinoids may be mediated by cannabinoid receptors in the hippocampus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02246292
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Comparative ultrastructure of the nerves innervating the muscle of the body of the bladder (1975)
    Springer
    Cell & tissue research 164 (1975), S. 133-144 
    Details
    ISSN: 1432-0878
    Keywords: Bladder body ; Mammals ; Musculature ; Innervation ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The distribution and structure of the nerves supplying the muscle of the body of the bladder in mammals such as the mouse, guinea-pig, rabbit, cat and dog was compared with that previously demonstrated in the rat. The muscle of the arterioles located between the muscle bundles is innervated by a fine perivascular plexus and the nerves forming the muscular plexus can be divided into inter-and intra-fascicular components. Terminals containing variable but usually small numbers of clear and large dense-cored vesicles are particularly numerous in the interfascicular nerves and the intrafascicular nerves are characterised by large numbers of terminals with the features of those of cholinergic axons. In addition to many small clear vesicles, the cholinergic terminals contained some small dense-cored vesicles, and it is suggested that, as in the rat, these contain a second transmitter which is released with acetylcholine at the terminals during impulse transmission. Adrenergic terminals are more common in the muscular plexuses of the guinea-pig, dog and cat than in those of the other animals studied and there is evidence for the presence of two types of such terminal in the nerves. Of these, one contains a much smaller proportion of small vesicles with dense cores and many more large dense-cored vesicles than the second, and the possibility of a relationship between such terminals and those of short adrenergic neurones and neurones associated with non-adrenergic patterns of impulse transmission is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00221700
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Comparative ultrastructure of ureteric innervation (1975)
    Springer
    Cell & tissue research 160 (1975), S. 515-524 
    Details
    ISSN: 1432-0878
    Keywords: Ureteric innervation ; Mammals ; Interspecies differences ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The distribution and structure of the ureteric nerves in a small series of mammals was compared with that previously demonstrated in the rat. There was marked interspecies variation in the extent to which the nerves penetrated the wall of the ureter and in the degree of development of the deep submucous plexus. In animals with a highly developed deep submucous plexus, terminal arterioles frequently passed through the muscle coat before breaking up into capillaries. These vessels were surrounded by a fine periarteriolar plexus and were accompanied in their course through the muscle coat by one or more branches of the adventitial nerves. Intramuscular nerves not related to arterioles contained few axons with terminals classifiable as either adrenergic or cholinergic, and in animals in which the muscle cells were arranged in fascicles rather than in sheets, the nerves were typically interfascicular in position. As in the rat, only the periarteriolar plexuses contained large numbers of adrenergic axons. Cholinergic axons were generally few, but were not uncommon in the deep submucous plexus when this was well-developed. The majority of the terminals encountered in the intramural nerves contained variable and usually small numbers of both clear and large dense-cored vesicles. The relationship between these terminals and those defined in the submucous nerves of the rat ureter was discussed and it was suggested that the marked variations in the diameter of the axons in the terminal areas and in the number of vesicles in the terminals were related to the effects of the mechanical and other derangements which occur during processing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00225768
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...