ISSN:
1435-1463
Schlagwort(e):
Catechol-O-methyltransferase
;
polymorphism
;
Parkinson's disease
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Summary We report −108Met/Val polymorphism of the COMT gene in Japanese patients with Parkinson's disease (PD). The allele frequency for −108Val was higher in PD patients compared with controls, although the differences did not reach the statistical significance. However, the frequency of -108Val homozygotes was significantly higher in PD patients (56.8%) than in control subjects (44.2%), and heterozygotes of −108Met/Val were less in PD. COMT gene polymorphism may constitute a genetic risk factor for PD among Japanese.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF01294732
Permalink