ISSN:
1432-2072
Keywords:
d-Amphetamine Sulfate
;
Dopamine Antagonist
;
Noradrenaline Antagonist
;
Nucleus Accumbens
;
Caudate Nucleus
;
Locomotor Activity
;
Haloperidol
;
Phentolamine
;
Propranolol
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The effect of intracerebral administration of antagonists of dopamine and noradrenaline upon the locomotor stimulation induced by intraperitoneal injection of d-amphetamine sulfate in rats was investigated. Injection of low doses of the dopamine antagonist haloperidol (2.5 Μg and 5 Μg) bilaterally into the nucleus accumbens antagonized the locomotor stimulation following d-amphetamine. No significant inhibition was observed following administration of the alpha-adrenergic antagonist phentolamine or the beta-adrenergic antagonist propranolol into the nucleus accumbens. Injection of the same doses of haloperidol into the caudate nucleus did not inhibit the d-amphetamine induced locomotor activity, in contrast to the effects seen following injection into the nucleus accumbens. The results confirm the significance of dopaminergic mechanisms for the locomotor stimulant effect of d-amphetamine and indicate that the mesolimbic dopamine system plays an important role in this respect.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00421062
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